Systemic lupus erythematosus (SLE) is characterized by circulating IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components. Immune complexes comprising autoantibody and self-antigen is deposited particulary in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc-gamma-R-mediated neutrophil and macrophage activation. Activation of complement leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases.

Local Unique Identifier

M4741

Xref KEGG Pathways Database

kegg.pathway:hsa05322

Relation in taxon (RO:0002162 )

• NCBITaxon:9606

Relation has part (BFO:0000051 )

• ncbigene:941
• ncbigene:942
• ncbigene:128312
• ncbigene:940
• ncbigene:9555
• ncbigene:340096
• ncbigene:221613
• ncbigene:3013
• ncbigene:92815
• ncbigene:3012
• ncbigene:2209
• ncbigene:317772
• ncbigene:126961
• ncbigene:723790
• ncbigene:735
• ncbigene:1511
• ncbigene:391769
• ncbigene:8294
• ncbigene:2215
• ncbigene:2212
• ncbigene:731
• ncbigene:8290
• ncbigene:730
• ncbigene:2214
• ncbigene:733
• ncbigene:2213
• ncbigene:732
• ncbigene:3126
• ncbigene:3127
• ncbigene:3125
• ncbigene:729
• ncbigene:727
• ncbigene:1991
• ncbigene:121504
• ncbigene:721
• ncbigene:720
• ncbigene:554313
• ncbigene:3113
• ncbigene:83740
• ncbigene:3115
• ncbigene:3117
• ncbigene:3118
• ncbigene:3119
• ncbigene:8370
• ncbigene:3018
• ncbigene:3014
• ncbigene:3015
• ncbigene:3017
• ncbigene:717
• ncbigene:3021
• ncbigene:716
• ncbigene:718
• ncbigene:713
• ncbigene:85235
• ncbigene:712
• ncbigene:3020
• ncbigene:715
• ncbigene:714
• ncbigene:85236
• ncbigene:88
• ncbigene:3123
• ncbigene:89
• ncbigene:3122
• ncbigene:8969
• ncbigene:3111
• ncbigene:3112
• ncbigene:8968
• ncbigene:7124
• ncbigene:8360
• ncbigene:9103
• ncbigene:8362
• ncbigene:55506
• ncbigene:8361
• ncbigene:94239
• ncbigene:8364
• ncbigene:8363
• ncbigene:8366
• ncbigene:3109
• ncbigene:8365
• ncbigene:3108
• ncbigene:81
• ncbigene:8368
• ncbigene:8970
• ncbigene:87
• ncbigene:8367
• ncbigene:8369
• ncbigene:158983
• ncbigene:8349
• ncbigene:2903
• ncbigene:2904
• ncbigene:6738
• ncbigene:6737
• ncbigene:8351
• ncbigene:8350
• ncbigene:440689
• ncbigene:8355
• ncbigene:8354
• ncbigene:8353
• ncbigene:8352
• ncbigene:8359
• ncbigene:3586
• ncbigene:8358
• ncbigene:6741
• ncbigene:8357
• ncbigene:333932
• ncbigene:8356
• ncbigene:286436
• ncbigene:474382
• ncbigene:440093
• ncbigene:8338
• ncbigene:8339
• ncbigene:474381
• ncbigene:55766
• ncbigene:6634
• ncbigene:100509927
• ncbigene:3458
• ncbigene:8340
• ncbigene:8346
• ncbigene:8345
• ncbigene:8348
• ncbigene:8347
• ncbigene:8342
• ncbigene:8341
• ncbigene:8344
• ncbigene:8343
• ncbigene:959
• ncbigene:958
• ncbigene:6628
• ncbigene:8329
• ncbigene:653604
• ncbigene:8337
• ncbigene:8336
• ncbigene:6632
• ncbigene:8335
• ncbigene:8334
• ncbigene:8332
• ncbigene:8331
• ncbigene:255626
• ncbigene:8330

Property category_code

C2

Property sub_category_code

CP:KEGG

Property contributor

KEGG

Property exact_source

hsa05322

Property external_details_url

http://www.genome.jp/kegg/pathway/hsa/hsa05322.html