KEGG_GNRH_SIGNALING_PATHWAY

Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.

Local Unique Identifier
M1979
Xref KEGG Pathways Database
kegg.pathway:hsa04912
Relation in taxon (RO:0002162 )
Relation has part (BFO:0000051 )
Property category_code
C2
Property sub_category_code
CP:KEGG
Property contributor
KEGG
Property exact_source
hsa04912
Property external_details_url
http://www.genome.jp/kegg/pathway/hsa/hsa04912.html