Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.

Local Unique Identifier

M18937

Xref KEGG Pathways Database

kegg.pathway:hsa03420

Relation in taxon (RO:0002162 )

• NCBITaxon:9606

Relation has part (BFO:0000051 )

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• ncbigene:2968
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Property category_code

C2

Property sub_category_code

CP:KEGG

Property contributor

KEGG

Property exact_source

hsa03420

Property external_details_url

http://www.genome.jp/kegg/pathway/hsa/hsa03420.html