Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.

Local Unique Identifier

M11675

Xref KEGG Pathways Database

kegg.pathway:hsa03440

Relation in taxon (RO:0002162 )

• NCBITaxon:9606

Relation has part (BFO:0000051 )

• ncbigene:8438
• ncbigene:7517
• ncbigene:5890
• ncbigene:4683
• ncbigene:5893
• ncbigene:5892
• ncbigene:7516
• ncbigene:57804
• ncbigene:641
• ncbigene:146956
• ncbigene:6117
• ncbigene:5888
• ncbigene:10714
• ncbigene:10111
• ncbigene:6119
• ncbigene:6118
• ncbigene:29935
• ncbigene:5889
• ncbigene:4361
• ncbigene:675
• ncbigene:5424
• ncbigene:5425
• ncbigene:80198
• ncbigene:7156
• ncbigene:25788
• ncbigene:7979
• ncbigene:8940
• ncbigene:6742

Property category_code

C2

Property sub_category_code

CP:KEGG

Property contributor

KEGG

Property exact_source

hsa03440

Property external_details_url

http://www.genome.jp/kegg/pathway/hsa/hsa03440.html