KEGG_MAPK_SIGNALING_PATHWAY

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.

Local Unique Identifier
M10792
Xref KEGG Pathways Database
kegg.pathway:hsa04010
Relation in taxon (RO:0002162 )
Relation has part (BFO:0000051 )
Property category_code
C2
Property sub_category_code
CP:KEGG
Property contributor
KEGG
Property exact_source
hsa04010
Property external_details_url
http://www.genome.jp/kegg/pathway/hsa/hsa04010.html