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Hdc Gene Detail
Summary
  • Symbol
    Hdc
  • Name
    histidine decarboxylase
  • Synonyms
    Hdc-a, Hdc-c, Hdc-e, Hdc-s, L-histidine decarboxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:96062
    NCBI Gene: 15186
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:126435587-126461219 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 61.76 cM, cytoband E5-G
  • Mapping Data
    33 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96062
 protein coding gene Chr2:126435579-126465942 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026441
 protein coding gene Chr2:129816504-129839845 (-)
A/J MGP_AJ_G0026404
 protein coding gene Chr2:124554960-124582468 (-)
AKR/J MGP_AKRJ_G0026380
 protein coding gene Chr2:128128437-128149952 (-)
BALB/cJ MGP_BALBcJ_G0026416
 protein coding gene Chr2:124825721-124850252 (-)
C3H/HeJ MGP_C3HHeJ_G0026160
 protein coding gene Chr2:128609030-128643119 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026862
 protein coding gene Chr2:133947392-133973855 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024239
 protein coding gene Chr2:119285078-119305954 (-)
CAST/EiJ MGP_CASTEiJ_G0025621
 protein coding gene Chr2:128838242-128861857 (-)
CBA/J MGP_CBAJ_G0026140
 protein coding gene Chr2:138848167-138881245 (-)
DBA/2J MGP_DBA2J_G0026274
 protein coding gene Chr2:123965494-123994509 (-)
FVB/NJ MGP_FVBNJ_G0026238
 protein coding gene Chr2:122622663-122652821 (-)
LP/J MGP_LPJ_G0026379
 protein coding gene Chr2:130077351-130103710 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026258
 protein coding gene Chr2:142929736-142954939 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026917
 protein coding gene Chr2:128141990-128172895 (-)
PWK/PhJ MGP_PWKPhJ_G0025357
 protein coding gene Chr2:123510340-123535090 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025159
 protein coding gene Chr2:127216230-127248989 (-)
WSB/EiJ MGP_WSBEiJ_G0025695
 protein coding gene Chr2:129032070-129053895 (-)



Homology
more
  • Human Ortholog
    HDC, histidine decarboxylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDC, histidine decarboxylase
  • Links
    NCBI Gene ID: 3067
    neXtProt AC: NX_P19113
    UniProt: P19113

  • Chr Location
    15q21.2; chr15:50241947-50265965 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hdc mouse models; 3 with human HDC associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 1 allele in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    139 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal mast cells, altered anxiety-related and nociceptive behavior, altered cognitive function, increased weight gain, visceral adiposity, increased amount of brown adipose tissue, impaired glucose tolerance, hyperinsulinemia, and hyperleptinemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1071
  • Tissues
    238
  • cDNA Data
    56
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027360 Ensembl Gene Model | MGI Sequence Detail 25633 C57BL/6J ±  kb
    transcript ENSMUST00000028838 Ensembl | MGI Sequence Detail 2392 Not Applicable  
    polypeptide ENSMUSP00000028838 Ensembl | MGI Sequence Detail 662 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 1
      cDNA 60
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10682, MGD-MRK-10683, MGD-MRK-10684, MGD-MRK-10685, MGD-MRK-10686, MGI:2139302, MGI:96063, MGI:96064, MGI:96065, MGI:96066
    References
    more
    • Summaries
      All 232
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 8
      Phenotypes 139
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:343233 Kim KH, et al., Role of histamine-mediated macrophage differentiation in clearance of metastatic bacterial infection. Front Immunol. 2023;14:1290191
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory