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Cs Gene Detail
Summary
  • Symbol
    Cs
  • Name
    citrate synthase
  • Synonyms
    2610511A05Rik, 9030605P22Rik, ahl4, Cis
  • Feature Type
    protein coding gene
  • IDs
    MGI:88529
    NCBI Gene: 12974
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128173603-128198348 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 76.53 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88529
 protein coding gene Chr10:128173596-128198351 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017860
 protein coding gene Chr10:132061214-132090618 (+)
A/J MGP_AJ_G0017835
 protein coding gene Chr10:126762799-126788641 (+)
AKR/J MGP_AKRJ_G0017798
 protein coding gene Chr10:130487867-130512569 (+)
BALB/cJ MGP_BALBcJ_G0017799
 protein coding gene Chr10:127147098-127171607 (+)
C3H/HeJ MGP_C3HHeJ_G0017622
 protein coding gene Chr10:130650876-130675925 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018254
 protein coding gene Chr10:136543302-136570710 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015932
 protein coding gene Chr10:120700667-120725286 (+)
CAST/EiJ MGP_CASTEiJ_G0017183
 protein coding gene Chr10:131355806-131381602 (+)
CBA/J MGP_CBAJ_G0017592
 protein coding gene Chr10:142088086-142117786 (+)
DBA/2J MGP_DBA2J_G0017698
 protein coding gene Chr10:125823814-125849195 (+)
FVB/NJ MGP_FVBNJ_G0017693
 protein coding gene Chr10:124752408-124778934 (+)
LP/J MGP_LPJ_G0017772
 protein coding gene Chr10:132657673-132686988 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017721
 protein coding gene Chr10:144670757-144706901 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018294
 protein coding gene Chr10:130584088-130611287 (+)
PWK/PhJ MGP_PWKPhJ_G0016968
 protein coding gene Chr10:126084590-126109568 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016757
 protein coding gene Chr10:129679388-129705427 (+)
WSB/EiJ MGP_WSBEiJ_G0017242
 protein coding gene Chr10:130799772-130825559 (+)



Homology
more
  • Human Ortholog
    CS, citrate synthase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CS, citrate synthase
  • Links
    NCBI Gene ID: 1431
    neXtProt AC: NX_O75390
    UniProt: O75390

  • Chr Location
    12q13.3; chr12:56271699-56300391 (-)  GRCh38
  • MGI Vertebrate Homology
    Cs stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: CS
  • Gene Tree
    Cs
Human Diseases
more
  • Diseases
    2 with human CS associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a point mutation exhibit hearing loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    839
  • Tissues
    102
  • cDNA Data
    14
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005683 Ensembl Gene Model | MGI Sequence Detail 24746 C57BL/6J ±  kb
    transcript ENSMUST00000005826 Ensembl | MGI Sequence Detail 2926 Not Applicable  
    polypeptide ENSMUSP00000005826 Ensembl | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1986, MGD-MRK-2184, MGI:1915151, MGI:1918798, MGI:2143907, MGI:3514039
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 11
      Gene Ontology 12
      Phenotypes 15
    • Earliest
      J:4573 Cox DR, et al., Comparative gene mapping in man and mouse: assignment of the gene for citrate synthase (Cis) to mouse Chromosome 10. Cytogenet Cell Genet. 1982;32:259 (Abstr.)
    • Latest
      J:345617 Beutner G, et al., Coordinated metabolic responses to cyclophilin D deletion in the developing heart. iScience. 2024 Mar 15;27(3):109157
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory