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Pycr1 Gene Detail
Summary
  • Symbol
    Pycr1
  • Name
    pyrroline-5-carboxylate reductase 1
  • Synonyms
    MGC:11688
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384795
    NCBI Gene: 209027
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120527591-120534602 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 84.37 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384795
 protein coding gene Chr11:120526538-120534602 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019518
 protein coding gene Chr11:125115727-125124008 (-)
A/J MGP_AJ_G0019486
 protein coding gene Chr11:119545781-119553715 (-)
AKR/J MGP_AKRJ_G0019456
 protein coding gene Chr11:123158466-123167951 (-)
BALB/cJ MGP_BALBcJ_G0019461
 protein coding gene Chr11:119903078-119912736 (-)
C3H/HeJ MGP_C3HHeJ_G0019267
 protein coding gene Chr11:123477730-123485633 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019909
 protein coding gene Chr11:128899534-128907469 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017535
 protein coding gene Chr11:116534838-116542604 (-)
CAST/EiJ MGP_CASTEiJ_G0018821
 protein coding gene Chr11:124980914-124990952 (-)
CBA/J MGP_CBAJ_G0019238
 protein coding gene Chr11:133935195-133945388 (-)
DBA/2J MGP_DBA2J_G0019350
 protein coding gene Chr11:118914088-118922253 (-)
FVB/NJ MGP_FVBNJ_G0019342
 protein coding gene Chr11:118626802-118635257 (-)
LP/J MGP_LPJ_G0019422
 protein coding gene Chr11:125417654-125425433 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019375
 protein coding gene Chr11:132776640-132784476 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019949
 protein coding gene Chr11:123828991-123838226 (-)
PWK/PhJ MGP_PWKPhJ_G0018587
 protein coding gene Chr11:120354504-120362749 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018379
 protein coding gene Chr11:123596021-123604451 (-)
WSB/EiJ MGP_WSBEiJ_G0018873
 protein coding gene Chr11:123818947-123828650 (-)



Homology
more
  • Human Ortholog
    PYCR1, pyrroline-5-carboxylate reductase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PYCR1, pyrroline-5-carboxylate reductase 1
  • Synonyms
    ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR
  • Links
    NCBI Gene ID: 5831
    neXtProt AC: NX_P32322
    UniProt: P32322

  • Chr Location
    17q25.3; chr17:81932384-81942412 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PYCR1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show no overt skeletal or integument phenotypes but are reported to exhibit male-specific impaired glucose tolerance and decreased circulating triglyceride levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    922
  • Tissues
    116
  • cDNA Data
    35
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 209027 NCBI Gene Model | MGI Sequence Detail 7012 C57BL/6J ±  kb
    transcript NM_001379085 RefSeq | MGI Sequence Detail 2378 C57BL/6  
    polypeptide Q922W5 UniProt | EBI | MGI Sequence Detail 309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013515 pyrroline-5-carboxylate reductase 1, mitochondrial
      (term hierarchy)
    • EC
      1.5.1.2
    • InterPro Domains
      IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
      IPR036291 NAD(P)-binding domain superfamily
      IPR000304 Pyrroline-5-carboxylate reductase
      IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal
      IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 35
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345302 Xue Z, et al., Metabolomic and transcriptomic studies of improvements in myocardial infarction due to Pycr1 deletion. J Cell Mol Med. 2023 Jan;27(1):89-100
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory