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Mpst Gene Detail
Summary
  • Symbol
    Mpst
  • Name
    mercaptopyruvate sulfurtransferase
  • Synonyms
    3MST
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179733
    NCBI Gene: 246221
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:78290918-78298213 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.47 cM, cytoband E2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179733
 protein coding gene Chr15:78290616-78298213 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022042
 protein coding gene Chr15:78600681-78607972 (+)
A/J MGP_AJ_G0022003
 protein coding gene Chr15:75905058-75912349 (+)
AKR/J MGP_AKRJ_G0021978
 protein coding gene Chr15:77993663-78000952 (+)
BALB/cJ MGP_BALBcJ_G0022009
 protein coding gene Chr15:75878417-75885708 (+)
C3H/HeJ MGP_C3HHeJ_G0021780
 protein coding gene Chr15:78011280-78018569 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022452
 protein coding gene Chr15:81703712-81711001 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019982
 protein coding gene Chr15:72403025-72410544 (+)
CAST/EiJ MGP_CASTEiJ_G0021301
 protein coding gene Chr15:78688442-78695867 (+)
CBA/J MGP_CBAJ_G0021745
 protein coding gene Chr15:84224098-84231388 (+)
DBA/2J MGP_DBA2J_G0021874
 protein coding gene Chr15:75388390-75395683 (+)
FVB/NJ MGP_FVBNJ_G0021852
 protein coding gene Chr15:74388953-74396244 (+)
LP/J MGP_LPJ_G0021942
 protein coding gene Chr15:78806419-78813536 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021872
 protein coding gene Chr15:89419113-89426405 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022466
 protein coding gene Chr15:78036321-78043613 (+)
PWK/PhJ MGP_PWKPhJ_G0021043
 protein coding gene Chr15:75386927-75394300 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020880
 protein coding gene Chr15:77808480-77817484 (+)
WSB/EiJ MGP_WSBEiJ_G0021353
 protein coding gene Chr15:78388883-78396176 (+)



Homology
more
  • Human Ortholog
    MPST, mercaptopyruvate sulfurtransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MPST, mercaptopyruvate sulfurtransferase
  • Synonyms
    MST, TST2, TUM1
  • Links
    NCBI Gene ID: 4357
    neXtProt AC: NX_P25325
    UniProt: P25325

  • Chr Location
    22q12.3; chr22:37019635-37029821 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 2 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit reduced male fertility. Mice homozygous for a knock-out allele exhibit normal fertility but increased anxiety-related behaviors and increased serotonin metabolite levels in the brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 246221 NCBI Gene Model | MGI Sequence Detail 7296 C57BL/6J ±  kb
    transcript NM_138670 RefSeq | MGI Sequence Detail 1810 C57BL/6  
    polypeptide Q99J99 UniProt | EBI | MGI Sequence Detail 297 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 27
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 64
      Diseases 1
      Gene Ontology 11
      Phenotypes 36
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345900 Drekolia MK, et al., Loss of cardiac mitochondrial complex I persulfidation impairs NAD(+) homeostasis in aging. Redox Biol. 2024 Feb;69:103014
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory