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Rbm3 Gene Detail
Summary
  • Symbol
    Rbm3
  • Name
    RNA binding motif (RNP1, RRM) protein 3
  • Synonyms
    2600016C11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099460
    NCBI Gene: 19652
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:8005214-8012119 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 3.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099460
 protein coding gene ChrX:8005214-8012119 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035541
 protein coding gene ChrX:2785160-2792393 (-)
A/J MGP_AJ_G0035518
 protein coding gene ChrX:2761105-2767541 (-)
AKR/J MGP_AKRJ_G0035451
 protein coding gene ChrX:2874791-2884023 (-)
BALB/cJ MGP_BALBcJ_G0035515
 protein coding gene ChrX:2758358-2765771 (-)
C3H/HeJ MGP_C3HHeJ_G0035223
 protein coding gene ChrX:2841700-2849457 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036039
 protein coding gene ChrX:2880819-2887507 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032914
 protein coding gene ChrX:2286070-2292645 (-)
CAST/EiJ MGP_CASTEiJ_G0034524
 protein coding gene ChrX:2729570-2736690 (-)
CBA/J MGP_CBAJ_G0035193
 protein coding gene ChrX:3032792-3039291 (-)
DBA/2J MGP_DBA2J_G0035350
 protein coding gene ChrX:2746824-2753511 (-)
FVB/NJ MGP_FVBNJ_G0035297
 protein coding gene ChrX:2712502-2719746 (-)
LP/J MGP_LPJ_G0035427
 protein coding gene ChrX:2807407-2813613 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035337
 protein coding gene ChrX:2980567-2987789 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036057
 protein coding gene ChrX:2766790-2774368 (-)
PWK/PhJ MGP_PWKPhJ_G0034224
 protein coding gene ChrX:2688777-2695756 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034063
 protein coding gene ChrX:2745283-2752255 (-)
WSB/EiJ MGP_WSBEiJ_G0034647
 protein coding gene ChrX:2770556-2778435 (-)



Homology
more
  • Human Ortholog
    RBM3, RNA binding motif protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBM3, RNA binding motif protein 3
  • Synonyms
    IS1-RNPL, RNPL
  • Links
    NCBI Gene ID: 5935
    neXtProt AC: NX_P98179
    UniProt: P98179

  • Chr Location
    Xp11.23; chrX:48574449-48581162 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased cell proliferation in mouse embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    54
  • cDNA Data
    22
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19652 NCBI Gene Model | MGI Sequence Detail 6906 C57BL/6J ±  kb
    transcript NM_016809 RefSeq | MGI Sequence Detail 2978 ZRU/MplStud  
    polypeptide O89086 UniProt | EBI | MGI Sequence Detail 153 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 1
      cDNA 26
      Primer pair 3
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1919317
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 20
    • Earliest
      J:43904 Derry JM, et al., RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain. Hum Mol Genet. 1995 Dec;4(12):2307-11
    • Latest
      J:339223 Nakamura J, et al., Cold shock protein RBM3 is upregulated in the autophagy-deficient brain. MicroPubl Biol. 2022;2022
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory