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Hnrnpa2b1 Gene Detail
Summary
  • Symbol
    Hnrnpa2b1
  • Name
    heterogeneous nuclear ribonucleoprotein A2/B1
  • Synonyms
    9130414A06Rik, Hnrpa2, Hnrpa2b1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104819
    NCBI Gene: 53379
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:51437912-51446874 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 24.87 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104819
protein coding gene Chr6:51437414-51448054 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030734
protein coding gene Chr6:50649570-50658532 (-)
A/J MGP_AJ_G0030704
protein coding gene Chr6:48283507-48294213 (-)
AKR/J MGP_AKRJ_G0030630
protein coding gene Chr6:49967897-49976862 (-)
BALB/cJ MGP_BALBcJ_G0030715
protein coding gene Chr6:48639212-48651228 (-)
C3H/HeJ MGP_C3HHeJ_G0030429
protein coding gene Chr6:49985417-49994379 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031170
protein coding gene Chr6:51771434-51780396 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028377
protein coding gene Chr6:45955520-45965425 (-)
CAST/EiJ MGP_CASTEiJ_G0029831
protein coding gene Chr6:49753486-49762445 (-)
CBA/J MGP_CBAJ_G0030402
protein coding gene Chr6:53941252-53950215 (-)
DBA/2J MGP_DBA2J_G0030552
protein coding gene Chr6:48208176-48217138 (-)
FVB/NJ MGP_FVBNJ_G0030504
protein coding gene Chr6:47827186-47836149 (-)
LP/J MGP_LPJ_G0030637
protein coding gene Chr6:50618281-50627242 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030538
protein coding gene Chr6:56599423-56608636 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031200
protein coding gene Chr6:49886762-49895723 (-)
PWK/PhJ MGP_PWKPhJ_G0029544
protein coding gene Chr6:47810143-47820001 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029379
protein coding gene Chr6:49226634-49236599 (-)
WSB/EiJ MGP_WSBEiJ_G0029908
protein coding gene Chr6:49873774-49883455 (-)



Homology
more
  • Human Ortholog
    HNRNPA2B1, heterogeneous nuclear ribonucleoprotein A2/B1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HNRNPA2B1, heterogeneous nuclear ribonucleoprotein A2/B1
  • Synonyms
    HNRNPA2, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, IBMPFD2, OPMD2, RNPA2, SNRPB1
  • Links
    NCBI Gene ID: 3181
    neXtProt AC: NX_P22626
    UniProt: P22626

  • Chr Location
    7p15.2; chr7:26171151-26201529 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with human HNRNPA2B1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004980 Ensembl Gene Model | MGI Sequence Detail 8963 C57BL/6J ±  kb
    transcript ENSMUST00000203954 Ensembl | MGI Sequence Detail 1703 Not Applicable  
    polypeptide ENSMUSP00000145028 Ensembl | MGI Sequence Detail 353 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000008660 heterogeneous nuclear ribonucleoproteins A2/B1
    • InterPro Domains
      IPR021662 Heterogeneous nuclear ribonucleoprotein A1/A2, C-terminal
      IPR034486 hnRNP A2/B1, RNA recognition motif 1
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 400
      cDNA 397
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-28113, MGI:1918855
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:23142 Ferreira J, et al., The biogenesis of the coiled body during early mouse development. Development. 1995 Feb;121(2):601-12
    • Latest
      J:339368 Yao F, et al., Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis. Cell Death Dis. 2023 Aug 23;14(8):543

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory