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Cad Gene Detail
Summary
  • Symbol
    Cad
  • Name
    carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
  • Synonyms
    2410008J01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916969
    NCBI Gene: 69719
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:31212124-31235823 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 16.95 cM, cytoband B1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    133 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916969
 protein coding gene Chr5:31211964-31235823 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029407
 protein coding gene Chr5:29024215-29051280 (+)
A/J MGP_AJ_G0029373
 protein coding gene Chr5:28080069-28104824 (+)
AKR/J MGP_AKRJ_G0029324
 protein coding gene Chr5:29231354-29255384 (+)
BALB/cJ MGP_BALBcJ_G0029384
 protein coding gene Chr5:28597472-28622096 (+)
C3H/HeJ MGP_C3HHeJ_G0029105
 protein coding gene Chr5:29244266-29268256 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029837
 protein coding gene Chr5:30817218-30841818 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027075
 protein coding gene Chr5:25549970-25573008 (+)
CAST/EiJ MGP_CASTEiJ_G0028515
 protein coding gene Chr5:28329386-28353126 (+)
CBA/J MGP_CBAJ_G0029073
 protein coding gene Chr5:31391957-31419182 (+)
DBA/2J MGP_DBA2J_G0029222
 protein coding gene Chr5:28258170-28281930 (+)
FVB/NJ MGP_FVBNJ_G0029180
 protein coding gene Chr5:27675906-27699954 (+)
LP/J MGP_LPJ_G0029307
 protein coding gene Chr5:29485247-29510490 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029209
 protein coding gene Chr5:32270250-32295865 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029871
 protein coding gene Chr5:28738587-28762116 (+)
PWK/PhJ MGP_PWKPhJ_G0028240
 protein coding gene Chr5:27380320-27405322 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028070
 protein coding gene Chr5:28111500-28139546 (+)
WSB/EiJ MGP_WSBEiJ_G0028596
 protein coding gene Chr5:28803801-28829416 (+)



Homology
more
  • Human Ortholog
    CAD, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAD, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
  • Synonyms
    CDG1Z, DEE50, EIEE50, GATD4
  • Links
    NCBI Gene ID: 790
    neXtProt AC: NX_P27708
    UniProt: P27708

  • Chr Location
    2p23.3; chr2:27217369-27243943 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CAD associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    102
  • cDNA Data
    232
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000013629 Ensembl Gene Model | MGI Sequence Detail 23700 C57BL/6J ±  kb
transcript ENSMUST00000013773 Ensembl | MGI Sequence Detail 7137 Not Applicable  
polypeptide ENSMUSP00000013773 Ensembl | MGI Sequence Detail 2225 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000004959 multifunctional protein CAD
    (term hierarchy)
  • EC
    2.1.3.2, 3.5.1.2, 3.5.2.3, 6.3.4.16, 6.3.5.5
  • InterPro Domains
    IPR006680 Amidohydrolase-related
    IPR002082 Aspartate carbamoyltransferase
    IPR006130 Aspartate/ornithine carbamoyltransferase
    IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
    IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
    IPR036901 Aspartate/ornithine carbamoyltransferase superfamily
    IPR011761 ATP-grasp fold
    IPR013815 ATP-grasp fold, subdomain 1
    IPR006275 Carbamoyl-phosphate synthase, large subunit
    IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain
    IPR006274 Carbamoyl-phosphate synthase, small subunit
    IPR035686 Carbamoyl-phosphate synthase small subunit, GATase1 domain
    IPR002474 Carbamoyl-phosphate synthase small subunit, N-terminal domain
    IPR036480 Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily
    IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
    IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
    IPR036897 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily
    IPR029062 Class I glutamine amidotransferase-like
    IPR002195 Dihydroorotase, conserved site
    IPR017926 Glutamine amidotransferase
    IPR032466 Metal-dependent hydrolase
    IPR011059 Metal-dependent hydrolase, composite domain superfamily
    IPR011607 Methylglyoxal synthase-like domain
    IPR036914 Methylglyoxal synthase-like domain superfamily
    IPR016185 Pre-ATP-grasp domain superfamily
Molecular
Reagents
less
  • All nucleic 235
    Genomic 1
    cDNA 232
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGI:2141042
References
more
  • Summaries
    All 70
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 12
    Phenotypes 32
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory