About   Help   FAQ
Usp1 Gene Detail
Summary
  • Symbol
    Usp1
  • Name
    ubiquitin specific peptidase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385198
    NCBI Gene: 230484
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
  • Candidate for QTL
    5 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:98812047-98823780 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 45.60 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    62 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385198
 protein coding gene Chr4:98812047-98823780 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028476
 protein coding gene Chr4:99113833-99134420 (+)
A/J MGP_AJ_G0028439
 protein coding gene Chr4:95682365-95694454 (+)
AKR/J MGP_AKRJ_G0028386
 protein coding gene Chr4:97997496-98012831 (+)
BALB/cJ MGP_BALBcJ_G0028457
 protein coding gene Chr4:95924464-95936370 (+)
C3H/HeJ MGP_C3HHeJ_G0028170
 protein coding gene Chr4:98794398-98805868 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028896
 protein coding gene Chr4:102886672-102903246 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026188
 protein coding gene Chr4:91063309-91075228 (+)
CAST/EiJ MGP_CASTEiJ_G0027610
 protein coding gene Chr4:96580596-96598275 (+)
CBA/J MGP_CBAJ_G0028139
 protein coding gene Chr4:106041356-106055460 (+)
DBA/2J MGP_DBA2J_G0028289
 protein coding gene Chr4:95417048-95430414 (+)
FVB/NJ MGP_FVBNJ_G0028256
 protein coding gene Chr4:94258806-94270409 (+)
LP/J MGP_LPJ_G0028389
 protein coding gene Chr4:99443663-99456303 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028284
 protein coding gene Chr4:111778199-111790677 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028934
 protein coding gene Chr4:98242602-98259451 (+)
PWK/PhJ MGP_PWKPhJ_G0027335
 protein coding gene Chr4:93557824-93570256 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027156
 protein coding gene Chr4:95682050-95698304 (+)
WSB/EiJ MGP_WSBEiJ_G0027688
 protein coding gene Chr4:98377527-98391752 (+)



Homology
more
  • Human Ortholog
    USP1, ubiquitin specific peptidase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP1, ubiquitin specific peptidase 1
  • Synonyms
    UBP
  • Links
    NCBI Gene ID: 7398
    neXtProt AC: NX_O94782
    UniProt: O94782

  • Chr Location
    1p31.3; chr1:62436297-62451804 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Usp1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have a high rate of postnatal lethality related to cyanosis. Male survivors are infertile while female survivors have reduced fertility. Both sexes have reduced number of gametes, are sensitive to ionizing radiation, and have decreased numbers of bone marrow cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    6
  • cDNA Data
    126
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230484 NCBI Gene Model | MGI Sequence Detail 11734 C57BL/6J ±  kb
    transcript NM_001301414 RefSeq | MGI Sequence Detail 3608 C57BL/6  
    polypeptide Q8BJQ2 UniProt | EBI | MGI Sequence Detail 784 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 127
      cDNA 127

      Microarray probesets 5
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory