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Otud7a Gene Detail
Summary
  • Symbol
    Otud7a
  • Name
    OTU domain containing 7A
  • Synonyms
    Cezanne 2 protein, Otud7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158505
    NCBI Gene: 170711
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:63094499-63408776 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 34.52 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3246 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2158505
 protein coding gene Chr7:63094493-63415980 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032331
 protein coding gene Chr7:64504677-64860222 (+)
A/J MGP_AJ_G0032310
 protein coding gene Chr7:63304170-63635288 (+)
AKR/J MGP_AKRJ_G0032246
 protein coding gene Chr7:64648631-64974417 (+)
BALB/cJ MGP_BALBcJ_G0032322
 protein coding gene Chr7:62998394-63371804 (+)
C3H/HeJ MGP_C3HHeJ_G0032035
 protein coding gene Chr7:65302004-65616455 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032815
 protein coding gene Chr7:67308468-67652271 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029822
 protein coding gene Chr7:66294603-66596377 (+)
CAST/EiJ MGP_CASTEiJ_G0031364
 protein coding gene Chr7:55947784-56277794 (+)
CBA/J MGP_CBAJ_G0032001
 protein coding gene Chr7:69472161-69834201 (+)
DBA/2J MGP_DBA2J_G0032157
 protein coding gene Chr7:62065827-62372543 (+)
FVB/NJ MGP_FVBNJ_G0032111
 protein coding gene Chr7:62160126-62463391 (+)
LP/J MGP_LPJ_G0032237
 protein coding gene Chr7:65770602-66098083 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032148
 protein coding gene Chr7:69797062-70150372 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032832
 protein coding gene Chr7:63900965-64228846 (+)
PWK/PhJ MGP_PWKPhJ_G0031084
 protein coding gene Chr7:55067152-55383162 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030925
 protein coding gene Chr7:51037652-51379098 (+)
WSB/EiJ MGP_WSBEiJ_G0031482
 protein coding gene Chr7:64289423-64623812 (+)



Homology
more
  • Human Ortholog
    OTUD7A, OTU deubiquitinase 7A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OTUD7A, OTU deubiquitinase 7A
  • Synonyms
    C15orf16, C16ORF15, CEZANNE2, OTUD7
  • Links
    NCBI Gene ID: 161725
    neXtProt AC: NX_Q8TE49
    UniProt: Q8TE49

  • Chr Location
    15q13.3; chr15:31475398-31870789 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Otud7a mouse models

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced body weight, abnormal spike wave discharge, decreased dendritic spine density, decreased prepulse inhibition, impaired coordination, decreased grip strength, decreased startle reflex, impaired ultrasonic vocalization and delayed tooth eruption.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033510 Ensembl Gene Model | MGI Sequence Detail 314278 C57BL/6J ±  kb
    transcript ENSMUST00000058476 Ensembl | MGI Sequence Detail 3483 Not Applicable  
    polypeptide ENSMUSP00000057282 Ensembl | MGI Sequence Detail 926 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 46
      Diseases 3
      Gene Ontology 5
      Phenotypes 23
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:322231 Malwade S, et al., Identification of Vulnerable Interneuron Subtypes in 15q13.3 Microdeletion Syndrome Using Single-Cell Transcriptomics. Biol Psychiatry. 2022 Apr 15;91(8):727-739
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory