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Usp26 Gene Detail
Summary
  • Symbol
    Usp26
  • Name
    ubiquitin specific peptidase 26
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933247
    NCBI Gene: 83563
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:50842836-50890110 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 28.31 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933247
protein coding gene ChrX:50841544-50890110 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035713
protein coding gene ChrX:46945196-46991563 (-)
A/J MGP_AJ_G0035696
protein coding gene ChrX:46790926-46840427 (-)
AKR/J MGP_AKRJ_G0035616
protein coding gene ChrX:48100081-48148466 (-)
BALB/cJ MGP_BALBcJ_G0035682
protein coding gene ChrX:46372338-46418045 (-)
C3H/HeJ MGP_C3HHeJ_G0035386
protein coding gene ChrX:47202523-47251136 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036212
protein coding gene ChrX:48051776-48101672 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033063
protein coding gene ChrX:44313975-44351698 (-)
CAST/EiJ MGP_CASTEiJ_G0034677
protein coding gene ChrX:34645317-34692622 (-)
CBA/J MGP_CBAJ_G0035360
protein coding gene ChrX:49401388-49443340 (-)
DBA/2J MGP_DBA2J_G0035515
protein coding gene ChrX:46623002-46668464 (-)
FVB/NJ MGP_FVBNJ_G0035463
protein coding gene ChrX:46317811-46363443 (-)
LP/J MGP_LPJ_G0035602
protein coding gene ChrX:47253634-47301837 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035502
protein coding gene ChrX:50946367-50995246 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036229
protein coding gene ChrX:46841579-46883505 (-)
PWK/PhJ MGP_PWKPhJ_G0034376
protein coding gene ChrX:34147632-34193941 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034221
protein coding gene ChrX:35421107-35466965 (-)
WSB/EiJ MGP_WSBEiJ_G0034821
protein coding gene ChrX:46375752-46426689 (-)



Homology
more
  • Human Ortholog
    USP26, ubiquitin specific peptidase 26
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP26, ubiquitin specific peptidase 26
  • Synonyms
    SPGFX6
  • Links
    NCBI Gene ID: 83844
    neXtProt AC: NX_Q9BXU7
    UniProt: Q9BXU7

  • Chr Location
    Xq26.2; chrX:133023168-133097109 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human USP26 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for a null allele exhibit normal fecundity. Mice homozygous for a different allele exhibit male subfertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055780 Ensembl Gene Model | MGI Sequence Detail 47275 C57BL/6J ±  kb
    transcript ENSMUST00000114869 Ensembl | MGI Sequence Detail 4133 Not Applicable  
    polypeptide ENSMUSP00000110519 Ensembl | MGI Sequence Detail 835 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000017164 ubiquitin carboxyl-terminal hydrolase 26
    • EC
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR032069 Ubiquitin carboxyl-terminal hydrolase 37, pleckstrin homology-like domain
      IPR038093 Ubiquitin carboxyl-terminal hydrolase 37, pleckstrin homology-like domain superfamily
      IPR018200 Ubiquitin specific protease, conserved site
      IPR028889 Ubiquitin specific protease domain
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:68614 Wang PJ, et al., An abundance of X-linked genes expressed in spermatogonia. Nat Genet. 2001 Apr;27(4):422-6
    • Latest
      J:329968 Kazi S, et al., MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice. FASEB J. 2022 Sep;36(9):e22479

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory