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Eif3h Gene Detail
Summary
  • Symbol
    Eif3h
  • Name
    eukaryotic translation initiation factor 3, subunit H
  • Synonyms
    1110008A16Rik, 9430017H16Rik, EIF3-gamma, EIF3-P40, Eif3s3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915385
    NCBI Gene: 68135
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:51649956-51728901 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 19.42 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    465 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915385
 protein coding gene Chr15:51649954-51728919 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021837
 protein coding gene Chr15:50727973-50813292 (-)
A/J MGP_AJ_G0021797
 protein coding gene Chr15:48711173-48791801 (-)
AKR/J MGP_AKRJ_G0021778
 protein coding gene Chr15:50090881-50174503 (-)
BALB/cJ MGP_BALBcJ_G0021804
 protein coding gene Chr15:48973033-49054152 (-)
C3H/HeJ MGP_C3HHeJ_G0021578
 protein coding gene Chr15:50214851-50299418 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022243
 protein coding gene Chr15:52719668-52807906 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019780
 protein coding gene Chr15:45782980-45863856 (-)
CAST/EiJ MGP_CASTEiJ_G0021095
 protein coding gene Chr15:50764384-50847083 (-)
CBA/J MGP_CBAJ_G0021547
 protein coding gene Chr15:54634835-54718628 (-)
DBA/2J MGP_DBA2J_G0021671
 protein coding gene Chr15:48592359-48675202 (-)
FVB/NJ MGP_FVBNJ_G0021649
 protein coding gene Chr15:47789502-47874803 (-)
LP/J MGP_LPJ_G0021741
 protein coding gene Chr15:50526638-50608257 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021673
 protein coding gene Chr15:59626369-59707903 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022266
 protein coding gene Chr15:50431398-50514427 (-)
PWK/PhJ MGP_PWKPhJ_G0020840
 protein coding gene Chr15:48692181-48777219 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020677
 protein coding gene Chr15:50150409-50234385 (-)
WSB/EiJ MGP_WSBEiJ_G0021150
 protein coding gene Chr15:50418612-50499277 (-)



Homology
more
  • Human Ortholog
    EIF3H, eukaryotic translation initiation factor 3 subunit H
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF3H, eukaryotic translation initiation factor 3 subunit H
  • Synonyms
    eIF3-gamma, eIF3-p40, EIF3S3
  • Links
    NCBI Gene ID: 8667
    neXtProt AC: NX_O15372
    UniProt: O15372

  • Chr Location
    8q23.3-q24.11; chr8:116642130-116766925 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human EIF3H associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    39
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    31
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Eif3h
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    32 strains or lines available
Mice homozygous for an ENU-induced allele exhibit embryonic lethality. Heterozygous mice exhibit enhanced variegation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    772
  • Tissues
    45
  • cDNA Data
    390
  • Literature Summary
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68135 NCBI Gene Model | MGI Sequence Detail 78946 C57BL/6J ±  kb
transcript NM_080635 RefSeq | MGI Sequence Detail 1275 C57BL/6  
polypeptide Q91WK2 UniProt | EBI | MGI Sequence Detail 352 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 394
    cDNA 391
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
less
MGI:1915828
References
more
  • Summaries
    All 63
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 7
    Phenotypes 25
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:346383 Jin H, et al., The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression. Nat Commun. 2024 Mar 21;15(1):2551
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory