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Otud4 Gene Detail
Summary
  • Symbol
    Otud4
  • Name
    OTU domain containing 4
  • Synonyms
    4930431L18Rik, D8Ertd69e, mKIAA1046
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098801
    NCBI Gene: 73945
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:80366305-80404384 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 37.74 cM, cytoband C3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098801
 protein coding gene Chr8:80366247-80404384 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033813
 protein coding gene Chr8:80321831-80360978 (+)
A/J MGP_AJ_G0033795
 protein coding gene Chr8:77132292-77170357 (+)
AKR/J MGP_AKRJ_G0033722
 protein coding gene Chr8:79438359-79476410 (+)
BALB/cJ MGP_BALBcJ_G0033789
 protein coding gene Chr8:77233897-77274096 (+)
C3H/HeJ MGP_C3HHeJ_G0033498
 protein coding gene Chr8:80060585-80100402 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034309
 protein coding gene Chr8:83407867-83447571 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031250
 protein coding gene Chr8:71199239-71238532 (+)
CAST/EiJ MGP_CASTEiJ_G0032829
 protein coding gene Chr8:79401583-79439507 (+)
CBA/J MGP_CBAJ_G0033477
 protein coding gene Chr8:86346597-86384590 (+)
DBA/2J MGP_DBA2J_G0033630
 protein coding gene Chr8:76828268-76866862 (+)
FVB/NJ MGP_FVBNJ_G0033575
 protein coding gene Chr8:75797251-75836216 (+)
LP/J MGP_LPJ_G0033720
 protein coding gene Chr8:80399117-80438325 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033618
 protein coding gene Chr8:88902744-88941593 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034326
 protein coding gene Chr8:79451573-79495229 (+)
PWK/PhJ MGP_PWKPhJ_G0032532
 protein coding gene Chr8:76098112-76137129 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032370
 protein coding gene Chr8:78270864-78309345 (+)
WSB/EiJ MGP_WSBEiJ_G0032942
 protein coding gene Chr8:79789051-79827140 (+)



Homology
more
  • Human Ortholog
    OTUD4, OTU deubiquitinase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OTUD4, OTU deubiquitinase 4
  • Synonyms
    DUBA6, HIN1, HSHIN1
  • Links
    NCBI Gene ID: 54726
    neXtProt AC: NX_Q01804
    UniProt: Q01804

  • Chr Location
    4q31.21; chr4:145110838-145180589 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    45
  • cDNA Data
    20
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 73945 NCBI Gene Model | MGI Sequence Detail 38080 C57BL/6J ±  kb
transcript NM_001256033 RefSeq | MGI Sequence Detail 7327 ZRU/MplStud  
polypeptide B2RRE7 UniProt | EBI | MGI Sequence Detail 1107 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 20
    Primer pair 3

    Microarray probesets 8
Other
Accession IDs
less
MGI:1921195, MGI:2138957
References
more
  • Summaries
    All 45
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:326824 Kedia S, et al., Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation. Cell Rep. 2022 Jul 12;40(2):111070
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory