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Zranb1 Gene Detail
Summary
  • Symbol
    Zranb1
  • Name
    zinc finger, RAN-binding domain containing 1
  • Synonyms
    9330160G10Rik, D7Wsu87e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106441
    NCBI Gene: 360216
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:132532905-132588127 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 76.32 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    193 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106441
 protein coding gene Chr7:132532871-132588127 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033118
 protein coding gene Chr7:137641472-137696611 (+)
A/J MGP_AJ_G0033100
 protein coding gene Chr7:133850319-133903767 (+)
AKR/J MGP_AKRJ_G0033032
 protein coding gene Chr7:137421250-137476275 (+)
BALB/cJ MGP_BALBcJ_G0033101
 protein coding gene Chr7:133533554-133587693 (+)
C3H/HeJ MGP_C3HHeJ_G0032815
 protein coding gene Chr7:137254427-137309266 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033612
 protein coding gene Chr7:142903712-142943812 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030583
 protein coding gene Chr7:135149342-135185738 (+)
CAST/EiJ MGP_CASTEiJ_G0032145
 protein coding gene Chr7:129169613-129225077 (+)
CBA/J MGP_CBAJ_G0032788
 protein coding gene Chr7:147732771-147770562 (+)
DBA/2J MGP_DBA2J_G0032940
 protein coding gene Chr7:131883576-131918926 (+)
FVB/NJ MGP_FVBNJ_G0032893
 protein coding gene Chr7:131721748-131757006 (+)
LP/J MGP_LPJ_G0033034
 protein coding gene Chr7:139160838-139215343 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032925
 protein coding gene Chr7:148633481-148687850 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033632
 protein coding gene Chr7:136419099-136474559 (+)
PWK/PhJ MGP_PWKPhJ_G0031851
 protein coding gene Chr7:124887042-124939883 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031697
 protein coding gene Chr7:123189823-123241793 (+)
WSB/EiJ MGP_WSBEiJ_G0032256
 protein coding gene Chr7:137332244-137368117 (+)



Homology
more
  • Human Ortholog
    ZRANB1, zinc finger RANBP2-type containing 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZRANB1, zinc finger RANBP2-type containing 1
  • Synonyms
    TRABID
  • Links
    NCBI Gene ID: 54764
    neXtProt AC: NX_Q9UGI0
    UniProt: Q9UGI0

  • Chr Location
    10q26.13; chr10:124916894-124988189 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 5 alleles in 6 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knock-out allele leads to decreased CD4+ T cells and decreased susceptibility to experimental autoimmune encephalomyelitis. Homozygous enzymatic inactivation leads to reduced colon mucosa thickness and increased morbidity and mortality after DSS-induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    26
  • cDNA Data
    13
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 360216 NCBI Gene Model | MGI Sequence Detail 55223 C57BL/6J ±  kb
    transcript NR_155454 RefSeq | MGI Sequence Detail 5902 ZRU/MplStud  
    polypeptide Q7M760 UniProt | EBI | MGI Sequence Detail 708 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-34135, MGI:1924806, MGI:3037814
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:339387 Chen YH, et al., TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation. Nat Commun. 2023 May 26;14(1):3050
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory