Entry Name Hippo signaling pathway - multiple species - Homo sapiens (human)
Description Hippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evolution, with related forms described in animals and fungi. In Drosophila and mammals, Hippo/MST co-operate with Mats/Mob1 and Salvador/WW45 to activate Warts/LATS, which negatively regulates Yorkie/YAP. Yorkie/YAP interact with Scalloped/TEAD to promote gene transcriptions and control organ size through the balance between cell proliferation and apoptosis. In C. elegans, WTS-1 YAP-1 EGL-44 axis is conserved and regulates thermotolerance and healthy lifespan. In S. cerevisiae, the LATS-related Dbf2 or Dbf20 kinase in complex with Mob1 controls mitotic exit and cytokinesis, and the Hippo/MST family of kinases, STE-20, modulates Tec1, the putative yeast TEAD ortholog.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map hsa04392 Hippo signaling pathway - multiple species
Other DBs Organism Homo sapiens (human) [GN:
hsa ]
Gene 10413 YAP1; Yes1 associated transcriptional regulator [KO:K16687 ]
11186 RASSF1; Ras association domain family member 1 [KO:K09850 ]
166824 RASSF6; Ras association domain family member 6 [KO:K09854 ]
25937 WWTR1; WW domain containing transcription regulator 1 [KO:K16820 ]
4771 NF2; NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor [KO:K16684 ]
60485 SAV1; salvador family WW domain containing protein 1 [KO:K16686 ]
7003 TEAD1; TEA domain transcription factor 1 [KO:K09448 ]
7004 TEAD4; TEA domain transcription factor 4 [KO:K09448 ]
7005 TEAD3; TEA domain transcription factor 3 [KO:K09448 ]
83937 RASSF4; Ras association domain family member 4 [KO:K09851 ]
8463 TEAD2; TEA domain transcription factor 2 [KO:K09448 ]
8642 DCHS1; dachsous cadherin-related 1 [KO:K16507 ]
9770 RASSF2; Ras association domain family member 2 [KO:K09851 ]
Reference Authors Hilman D, Gat U
Title The evolutionary history of YAP and the hippo/YAP pathway.
Journal Reference Authors Varelas X
Title The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease.
Journal Reference Authors Zhao B, Tumaneng K, Guan KL
Title The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.
Journal Reference Authors Halder G, Johnson RL
Title Hippo signaling: growth control and beyond.
Journal Reference Authors Pan D
Title The hippo signaling pathway in development and cancer.
Journal Reference Authors Zhao B, Li L, Lei Q, Guan KL
Title The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.
Journal Reference Authors Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G
Title Hippo and rassf1a Pathways: A Growing Affair.
Journal Reference Authors Gogl G, Schneider KD, Yeh BJ, Alam N, Nguyen Ba AN, Moses AM, Hetenyi C, Remenyi A, Weiss EL
Title The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism.
Journal Reference Authors Iwasa H, Maimaiti S, Kuroyanagi H, Kawano S, Inami K, Timalsina S, Ikeda M, Nakagawa K, Hata Y
Title Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans.
Journal Reference Authors Yang Z, Hata Y
Title What is the Hippo pathway? Is the Hippo pathway conserved in Caenorhabditis elegans?
Journal Reference Authors Hotz M, Barral Y
Title The Mitotic Exit Network: new turns on old pathways.
Journal Reference Authors Rock JM, Lim D, Stach L, Ogrodowicz RW, Keck JM, Jones MH, Wong CC, Yates JR 3rd, Winey M, Smerdon SJ, Yaffe MB, Amon A
Title Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes.
Journal Reference Authors Hergovich A, Hemmings BA
Title Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways.
Journal Reference Authors Wang Y, Abu Irqeba A, Ayalew M, Suntay K
Title Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast.
Journal Related KO pathway 
