Entry Name Apoptosis - multiple species - Homo sapiens (human)
Description Apoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The major players are caspases, caspase inhibitors, members of the Bcl-2 family of pro- and anti-apoptotic proteins and adaptors of the Ced-4/APAF-1 type. Mammals, by comparison with Caenorhabditis and Drosophila, exhibit highly complex extrinsic and intrinsic pathways for apoptosis induction. However, recent analyses of whole genome sequences from cnidarians (e.g. Hydra) suggest that the caspase and Bcl-2 families were already highly complex in cnidarians and that Caenorhabditis and Drosophila lost many of the genes involved in apoptosis.
Class Cellular Processes; Cell growth and deathBRITE hierarchy
Pathway map Drug D12565 Xevinapant (JAN/USAN/INN)
Other DBs Organism Homo sapiens (human) [GN:
hsa ]
Gene 317 APAF1; apoptotic peptidase activating factor 1 [KO:K02084 ]
329 BIRC2; baculoviral IAP repeat containing 2 [KO:K16060 ]
330 BIRC3; baculoviral IAP repeat containing 3 [KO:K16060 ]
332 BIRC5; baculoviral IAP repeat containing 5 [KO:K08731 ]
4804 NGFR; nerve growth factor receptor [KO:K02583 ]
5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131 ]
56616 DIABLO; diablo IAP-binding mitochondrial protein [KO:K10522 ]
578 BAK1; BCL2 antagonist/killer 1 [KO:K14021 ]
581 BAX; BCL2 associated X, apoptosis regulator [KO:K02159 ]
596 BCL2; BCL2 apoptosis regulator [KO:K02161 ]
637 BID; BH3 interacting domain death agonist [KO:K04726 ]
666 BOK; BCL2 family apoptosis regulator BOK [KO:K02561 ]
7132 TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158 ]
79444 BIRC7; baculoviral IAP repeat containing 7 [KO:K16061 ]
8772 FADD; Fas associated via death domain [KO:K02373 ]
Reference Authors Fuchs Y, Steller H
Title Live to die another way: modes of programmed cell death and the signals emanating from dying cells.
Journal Reference Authors Kumar S, Cakouros D
Title Transcriptional control of the core cell-death machinery.
Journal Reference Authors Bergmann A, Steller H
Title Apoptosis, stem cells, and tissue regeneration.
Journal Reference Authors Zmasek CM, Godzik A
Title Evolution of the animal apoptosis network.
Journal Reference Authors Twomey C, McCarthy JV
Title Pathways of apoptosis and importance in development.
Journal Reference Authors Nicholson DW
Title Caspase structure, proteolytic substrates, and function during apoptotic cell death.
Journal Reference Authors Wang C, Youle RJ
Title The role of mitochondria in apoptosis*.
Journal Reference Authors Choi D, Woo M
Title Executioners of apoptosis in pancreatic {beta}-cells: not just for cell death.
Journal Reference Authors Joza N, Kroemer G, Penninger JM
Title Genetic analysis of the mammalian cell death machinery.
Journal Reference Authors Yan N, Wu JW, Chai J, Li W, Shi Y
Title Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.
Journal Reference Authors Reiter S, Crescenzi M, Galliot B, Buzgariu W
Title Hydra, a versatile model to study the homeostatic and developmental functions of cell death.
Journal Reference Authors Lasi M, Pauly B, Schmidt N, Cikala M, Stiening B, Kasbauer T, Zenner G, Popp T, Wagner A, Knapp RT, Huber AH, Grunert M, Soding J, David CN, Bottger A
Title The molecular cell death machinery in the simple cnidarian Hydra includes an expanded caspase family and pro- and anti-apoptotic Bcl-2 proteins.
Journal Reference Authors Lasi M, David CN, Bottger A
Title Apoptosis in pre-Bilaterians: Hydra as a model.
Journal Reference Authors Romero A, Novoa B, Figueras A
Title The complexity of apoptotic cell death in mollusks: An update.
Journal Reference Authors Potts MB, Cameron S
Title Cell lineage and cell death: Caenorhabditis elegans and cancer research.
Journal Reference Authors Lee EF, Young ND, Lim NT, Gasser RB, Fairlie WD
Title Apoptosis in schistosomes: toward novel targets for the treatment of schistosomiasis.
Journal Related KO pathway 
