KEGG   PATHWAY: hsa00100
Entry
hsa00100                    Pathway                                
Name
Steroid biosynthesis - Homo sapiens (human)
Class
Metabolism; Lipid metabolism
Pathway map
hsa00100  Steroid biosynthesis
hsa00100

Module
hsa_M00101  Cholesterol biosynthesis, FPP => cholesterol [PATH:hsa00100]
hsa_M00103  Cholecalciferol biosynthesis [PATH:hsa00100]
Network
  Element
N01624  Cholesterol biosynthesis
N01626  Cholecalciferol biosynthesis
Drug
D01202  Melinamide (JAN)
D03012  Avasimibe (USAN/INN)
D03025  Azalanstat dihydrochloride (USAN)
D03447  Cetaben sodium (USAN)
D03734  Eldacimibe (USAN/INN)
D03735  Lecimibide (USAN)
D06609  Lapaquistat acetate (JAN/USAN)
Other DBs
GO: 0016126
Organism
Homo sapiens (human) [GN:hsa]
Gene
2222  FDFT1; farnesyl-diphosphate farnesyltransferase 1 [KO:K00801] [EC:2.5.1.21]
6713  SQLE; squalene epoxidase [KO:K00511] [EC:1.14.14.17]
4047  LSS; lanosterol synthase [KO:K01852] [EC:5.4.99.7]
1595  CYP51A1; cytochrome P450 family 51 subfamily A member 1 [KO:K05917] [EC:1.14.14.154 1.14.15.36]
7108  TM7SF2; transmembrane 7 superfamily member 2 [KO:K00222] [EC:1.3.1.70]
3930  LBR; lamin B receptor [KO:K19532] [EC:1.3.1.70]
6307  MSMO1; methylsterol monooxygenase 1 [KO:K07750] [EC:1.14.18.9]
50814  NSDHL; NAD(P) dependent steroid dehydrogenase-like [KO:K07748] [EC:1.1.1.170]
51478  HSD17B7; hydroxysteroid 17-beta dehydrogenase 7 [KO:K13373] [EC:1.1.1.62 1.1.1.270]
10682  EBP; EBP cholestenol delta-isomerase [KO:K01824] [EC:5.3.3.5]
1718  DHCR24; 24-dehydrocholesterol reductase [KO:K09828] [EC:1.3.1.72 1.3.1.-]
6309  SC5D; sterol-C5-desaturase [KO:K00227] [EC:1.14.19.20]
1717  DHCR7; 7-dehydrocholesterol reductase [KO:K00213] [EC:1.3.1.21]
3988  LIPA; lipase A, lysosomal acid type [KO:K01052] [EC:3.1.1.13]
1056  CEL; carboxyl ester lipase [KO:K12298] [EC:3.1.1.13 3.1.1.3]
8435  SOAT2; sterol O-acyltransferase 2 [KO:K00637] [EC:2.3.1.26]
6646  SOAT1; sterol O-acyltransferase 1 [KO:K00637] [EC:2.3.1.26]
120227  CYP2R1; cytochrome P450 family 2 subfamily R member 1 [KO:K07419] [EC:1.14.14.24]
1594  CYP27B1; cytochrome P450 family 27 subfamily B member 1 [KO:K07438] [EC:1.14.15.18]
1591  CYP24A1; cytochrome P450 family 24 subfamily A member 1 [KO:K07436] [EC:1.14.15.16]
Compound
C00187  Cholesterol
C00448  trans,trans-Farnesyl diphosphate
C00751  Squalene
C01054  (S)-2,3-Epoxysqualene
C01164  7-Dehydrocholesterol
C01189  Lathosterol
C01561  Calcidiol
C01673  Calcitriol
C01694  Ergosterol
C01724  Lanosterol
C01753  beta-Sitosterol
C01789  Campesterol
C01802  Desmosterol
C01902  Cycloartenol
C01943  Obtusifoliol
C02141  Cycloeucalenol
C02530  Cholesterol ester
C03428  Presqualene diphosphate
C03845  5alpha-Cholest-8-en-3beta-ol
C04525  Fecosterol
C05103  4alpha-Methylzymosterol
C05107  7-Dehydrodesmosterol
C05108  14-Demethyllanosterol
C05109  24,25-Dihydrolanosterol
C05437  Zymosterol
C05439  5alpha-Cholesta-7,24-dien-3beta-ol
C05440  Ergosta-5,7,22,24(28)-tetraen-3beta-ol
C05441  Vitamin D2
C05442  Stigmasterol
C05443  Vitamin D3
C07712  Secalciferol
C08813  Brassicasterol
C08821  Isofucosterol
C08830  24-Methylidenecycloartanol
C11455  4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
C11508  4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
C11522  24-Methylenelophenol
C11523  24-Ethylidenelophenol
C15776  4alpha-Methylfecosterol
C15777  Episterol
C15780  5-Dehydroepisterol
C15781  24-Methylenecholesterol
C15782  Delta7-Avenasterol
C15783  5-Dehydroavenasterol
C15808  4alpha-Methylzymosterol-4-carboxylate
C15816  3-Keto-4-methylzymosterol
C15915  4,4-Dimethyl-5alpha-cholesta-8-en-3beta-ol
C18231  Calcitetrol
C21106  24-epi-Campesterol
C22112  4alpha-Carboxy-5alpha-cholesta-8,24-dien-3beta-ol
C22116  3beta-Hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-4alpha-carboxylate
C22119  3beta-Hydroxyergosta-7,24(24(1))-dien-4alpha-carboxylate
C22120  4alpha-Carboxy-stigmasta-7,24(24(1))-dien-3beta-ol
C22121  Cycloeucalenone
C22122  Episterone
C22123  Avenastenone
C22136  Zymosterone
Reference
  Authors
Koshiba K, Kamiya Y.
  Title
[Atarasii Syokubutuhorumon no Kagaku] (In Japanese)
  Journal
Koudansya saientific:199-138 (2002)
Reference
PMID:16531502
  Authors
Morikawa T, Mizutani M, Aoki N, Watanabe B, Saga H, Saito S, Oikawa A, Suzuki H, Sakurai N, Shibata D, Wadano A, Sakata K, Ohta D.
  Title
Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato.
  Journal
Plant Cell 18:1008-22 (2006)
DOI:10.1105/tpc.105.036012
Reference
PMID:12777052
  Authors
Lange BM, Ghassemian M.
  Title
Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism.
  Journal
Plant Mol Biol 51:925-48 (2003)
DOI:10.1023/A:1023005504702
Related
pathway
hsa00120  Primary bile acid biosynthesis
hsa00140  Steroid hormone biosynthesis
hsa00900  Terpenoid backbone biosynthesis
KO pathway
ko00100   
LinkDB

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