PATHWAY: mmu04060 Help
Entry
Name
Cytokine-cytokine receptor interaction - Mus musculus (house mouse)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
mmu04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
18829 Ccl21a; C-C motif chemokine ligand 21 (serine) [KO:K16062 ]
20301 Ccl27a; C-C motif chemokine ligand 27A [KO:K16598 ]
14825 Cxcl1; C-X-C motif chemokine ligand 1 [KO:K05505 ]
20310 Cxcl2; C-X-C motif chemokine ligand 2 [KO:K05505 ]
20311 Cxcl5; C-X-C motif chemokine ligand 5 [KO:K05506 ]
17329 Cxcl9; C-X-C motif chemokine ligand 9 [KO:K05416 ]
15945 Cxcl10; C-X-C motif chemokine ligand 10 [KO:K12671 ]
56066 Cxcl11; chemokine (C-X-C motif) ligand 11 [KO:K12672 ]
55985 Cxcl13; C-X-C motif chemokine ligand 13 [KO:K10032 ]
20315 Cxcl12; C-X-C motif chemokine ligand 12 [KO:K10031 ]
66102 Cxcl16; C-X-C motif chemokine ligand 16 [KO:K10035 ]
57266 Cxcl14; C-X-C motif chemokine ligand 14 [KO:K10033 ]
20309 Cxcl15; C-X-C motif chemokine ligand 15 [KO:K10034 ]
20312 Cx3cl1; C-X3-C motif chemokine ligand 1 [KO:K05508 ]
12981 Csf2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427 ]
19111 Prl6a1; prolactin family 6, subfamily a, member 1 [KO:K05439 ]
28078 Prl5a1; prolactin family 5, subfamily a, member 1 [KO:K05439 ]
12985 Csf3; colony stimulating factor 3 (granulocyte) [KO:K05423 ]
83430 Il23a; interleukin 23, alpha subunit p19 [KO:K05426 ]
50498 Ebi3; Epstein-Barr virus induced gene 3 [KO:K24476 ]
56708 Clcf1; cardiotrophin-like cytokine factor 1 [KO:K05421 ]
16181 Il1rn; interleukin 1 receptor antagonist [KO:K05481 ]
54450 Il36rn; interleukin 36 receptor antagonist [KO:K05483 ]
12977 Csf1; colony stimulating factor 1 (macrophage) [KO:K05453 ]
50930 Tnfsf14; tumor necrosis factor (ligand) superfamily, member 14 [KO:K05477 ]
326623 Tnfsf15; tumor necrosis factor (ligand) superfamily, member 15 [KO:K05478 ]
22035 Tnfsf10; tumor necrosis factor (ligand) superfamily, member 10 [KO:K04721 ]
18048 Klk1b4; kallikrein 1-related pepidase b4 [KO:K05451 ]
21943 Tnfsf11; tumor necrosis factor (ligand) superfamily, member 11 [KO:K05473 ]
21944 Tnfsf12; tumor necrosis factor (ligand) superfamily, member 12 [KO:K05474 ]
21949 Tnfsf8; tumor necrosis factor (ligand) superfamily, member 8 [KO:K05471 ]
21950 Tnfsf9; tumor necrosis factor (ligand) superfamily, member 9 [KO:K05472 ]
22164 Tnfsf4; tumor necrosis factor (ligand) superfamily, member 4 [KO:K05469 ]
240873 Tnfsf18; tumor necrosis factor (ligand) superfamily, member 18 [KO:K05479 ]
69583 Tnfsf13; tumor necrosis factor (ligand) superfamily, member 13 [KO:K05475 ]
24099 Tnfsf13b; tumor necrosis factor (ligand) superfamily, member 13b [KO:K05476 ]
21803 Tgfb1; transforming growth factor, beta 1 [KO:K13375 ]
21808 Tgfb2; transforming growth factor, beta 2 [KO:K13376 ]
21809 Tgfb3; transforming growth factor, beta 3 [KO:K13377 ]
23886 Gdf15; growth differentiation factor 15 [KO:K05504 ]
12165 Gdf2; growth differentiation factor 2 [KO:K05503 ]
14560 Gdf10; growth differentiation factor 10 [KO:K22674 ]
14561 Gdf11; growth differentiation factor 11 [KO:K22679 ]
14559 Gdf1; growth differentiation factor 1 [KO:K05495 ]
14562 Gdf3; growth differentiation factor 3 [KO:K22672 ]
14566 Gdf9; growth differentiation factor 9 [KO:K22673 ]
14563 Gdf5; growth differentiation factor 5 [KO:K04664 ]
12770 Ccr1l1; C-C motif chemokine receptor 1 like 1 [KO:K04176 ]
12777 Ccr10; C-C motif chemokine receptor 10 [KO:K04185 ]
12765 Cxcr2; C-X-C motif chemokine receptor 2 [KO:K05050 ]
12766 Cxcr3; C-X-C motif chemokine receptor 3 [KO:K04188 ]
12145 Cxcr5; C-X-C motif chemokine receptor 5 [KO:K04190 ]
12767 Cxcr4; C-X-C motif chemokine receptor 4 [KO:K04189 ]
80901 Cxcr6; C-X-C motif chemokine receptor 6 [KO:K04191 ]
13051 Cx3cr1; C-X3-C motif chemokine receptor 1 [KO:K04192 ]
16184 Il2ra; interleukin 2 receptor, alpha chain [KO:K05068 ]
16185 Il2rb; interleukin 2 receptor, beta chain [KO:K05069 ]
16186 Il2rg; interleukin 2 receptor, gamma chain [KO:K05070 ]
16169 Il15ra; interleukin 15 receptor, alpha chain [KO:K05074 ]
57914 Crlf2; cytokine receptor-like factor 2 [KO:K05078 ]
16188 Il3ra; interleukin 3 receptor, alpha chain [KO:K04737 ]
12984 Csf2rb2; colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) [KO:K04738 ]
12983 Csf2rb; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) [KO:K04738 ]
12982 Csf2ra; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) [KO:K05066 ]
16164 Il13ra1; interleukin 13 receptor, alpha 1 [KO:K05076 ]
16165 Il13ra2; interleukin 13 receptor, alpha 2 [KO:K05077 ]
17480 Mpl; myeloproliferative leukemia virus oncogene [KO:K05082 ]
12986 Csf3r; colony stimulating factor 3 receptor [KO:K05061 ]
16195 Il6st; interleukin 6 signal transducer [KO:K05060 ]
16157 Il11ra1; interleukin 11 receptor subunit alpha 1 [KO:K05056 ]
16158 Il11ra2; interleukin 11 receptor subunit alpha 2 [KO:K05056 ]
16161 Il12rb1; interleukin 12 receptor, beta 1 [KO:K05063 ]
16162 Il12rb2; interleukin 12 receptor, beta 2 [KO:K05064 ]
50931 Il27ra; interleukin 27 receptor, alpha [KO:K19598 ]
12804 Cntfr; ciliary neurotrophic factor receptor [KO:K05059 ]
16154 Il10ra; interleukin 10 receptor, alpha [KO:K05134 ]
16155 Il10rb; interleukin 10 receptor, beta [KO:K05135 ]
230828 Il22ra1; interleukin 22 receptor, alpha 1 [KO:K05138 ]
15975 Ifnar1; interferon (alpha and beta) receptor 1 [KO:K05130 ]
15976 Ifnar2; interferon (alpha and beta) receptor 2 [KO:K05131 ]
16177 Il1r1; interleukin 1 receptor, type I [KO:K04386 ]
16180 Il1rap; interleukin 1 receptor accessory protein [KO:K04723 ]
16178 Il1r2; interleukin 1 receptor, type II [KO:K04387 ]
16174 Il18rap; interleukin 18 receptor accessory protein [KO:K05174 ]
17082 Il1rl1; interleukin 1 receptor-like 1 [KO:K05171 ]
21937 Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158 ]
21938 Tnfrsf1b; tumor necrosis factor receptor superfamily, member 1b [KO:K05141 ]
230979 Tnfrsf14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) [KO:K05152 ]
85030 Tnfrsf25; tumor necrosis factor receptor superfamily, member 25 [KO:K05160 ]
21933 Tnfrsf10b; tumor necrosis factor receptor superfamily, member 10b [KO:K04722 ]
94185 Tnfrsf21; tumor necrosis factor receptor superfamily, member 21 [KO:K05157 ]
18053 Ngfr; nerve growth factor receptor (TNFR superfamily, member 16) [KO:K02583 ]
18383 Tnfrsf11b; tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) [KO:K05148 ]
21934 Tnfrsf11a; tumor necrosis factor receptor superfamily, member 11a, NFKB activator [KO:K05147 ]
27279 Tnfrsf12a; tumor necrosis factor receptor superfamily, member 12a [KO:K05149 ]
21941 Tnfrsf8; tumor necrosis factor receptor superfamily, member 8 [KO:K05145 ]
21942 Tnfrsf9; tumor necrosis factor receptor superfamily, member 9 [KO:K05146 ]
22163 Tnfrsf4; tumor necrosis factor receptor superfamily, member 4 [KO:K05142 ]
21936 Tnfrsf18; tumor necrosis factor receptor superfamily, member 18 [KO:K05154 ]
21935 Tnfrsf17; tumor necrosis factor receptor superfamily, member 17 [KO:K05153 ]
57916 Tnfrsf13b; tumor necrosis factor receptor superfamily, member 13b [KO:K05150 ]
72049 Tnfrsf13c; tumor necrosis factor receptor superfamily, member 13c [KO:K05151 ]
29820 Tnfrsf19; tumor necrosis factor receptor superfamily, member 19 [KO:K05155 ]
320100 Relt; RELT tumor necrosis factor receptor [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
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