KEGG   PATHWAY: mmu00564
Entry
mmu00564                    Pathway                                
Name
Glycerophospholipid metabolism - Mus musculus (house mouse)
Class
Metabolism; Lipid metabolism
Pathway map
mmu00564  Glycerophospholipid metabolism
mmu00564

Module
mmu_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:mmu00564]
mmu_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:mmu00564]
mmu_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:mmu00564]
Other DBs
GO: 0006650
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
14555  Gpd1; glycerol-3-phosphate dehydrogenase 1 (soluble) [KO:K00006] [EC:1.1.1.8]
333433  Gpd1l; glycerol-3-phosphate dehydrogenase 1-like [KO:K00006] [EC:1.1.1.8]
14571  Gpd2; glycerol phosphate dehydrogenase 2, mitochondrial [KO:K00111] [EC:1.1.5.3]
14732  Gpam; glycerol-3-phosphate acyltransferase, mitochondrial [KO:K00629] [EC:2.3.1.15]
215456  Gpat2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
102247  Gpat4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
231510  Gpat3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
55979  Agpat1; 1-acylglycerol-3-phosphate O-acyltransferase 1 [KO:K13509] [EC:2.3.1.51]
67512  Agpat2; 1-acylglycerol-3-phosphate O-acyltransferase 2 [KO:K13509] [EC:2.3.1.51]
28169  Agpat3; 1-acylglycerol-3-phosphate O-acyltransferase 3 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
68262  Agpat4; 1-acylglycerol-3-phosphate O-acyltransferase 4 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
52123  Agpat5; 1-acylglycerol-3-phosphate O-acyltransferase 5 [KO:K19007] [EC:2.3.1.51]
225010  Lclat1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
218121  Mboat1; membrane bound O-acyltransferase domain containing 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
67216  Mboat2; membrane bound O-acyltransferase domain containing 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
14712  Gnpat; glyceronephosphate O-acyltransferase [KO:K00649] [EC:2.3.1.42]
66358  Adprm; ADP-ribose/CDP-alcohol diphosphatase, manganese dependent [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
19012  Plpp1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
50784  Plpp2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
67916  Plpp3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
14245  Lpin1; lipin 1 [KO:K15728] [EC:3.1.3.4]
64899  Lpin3; lipin 3 [KO:K15728] [EC:3.1.3.4]
64898  Lpin2; lipin 2 [KO:K15728] [EC:3.1.3.4]
71910  Plpp5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
381925  Plpp4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
13139  Dgka; diacylglycerol kinase, alpha [KO:K00901] [EC:2.7.1.107]
110197  Dgkg; diacylglycerol kinase, gamma [KO:K00901] [EC:2.7.1.107]
110524  Dgkq; diacylglycerol kinase, theta [KO:K00901] [EC:2.7.1.107]
104418  Dgkz; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
217480  Dgkb; diacylglycerol kinase, beta [KO:K00901] [EC:2.7.1.107]
56077  Dgke; diacylglycerol kinase, epsilon [KO:K00901] [EC:2.7.1.107]
320127  Dgki; diacylglycerol kinase, iota [KO:K00901] [EC:2.7.1.107]
380921  Dgkh; diacylglycerol kinase, eta [KO:K00901] [EC:2.7.1.107]
227333  Dgkd; diacylglycerol kinase, delta [KO:K00901] [EC:2.7.1.107]
331374  Dgkk; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
212862  Chpt1; choline phosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
99712  Cept1; choline/ethanolaminephosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
18806  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
18805  Pld1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
18807  Pld3; phospholipase D family member 3 [KO:K16860] [EC:3.1.4.4]
104759  Pld4; phospholipase D family member 4 [KO:K16860] [EC:3.1.4.4]
16816  Lcat; lecithin cholesterol acyltransferase [KO:K00650] [EC:2.3.1.43]
26971  Pla2g2f; phospholipase A2, group IIF [KO:K01047] [EC:3.1.1.4]
18778  Pla2g1b; phospholipase A2, group IB, pancreas [KO:K01047] [EC:3.1.1.4]
18781  Pla2g2c; phospholipase A2, group IIC [KO:K01047] [EC:3.1.1.4]
18784  Pla2g5; phospholipase A2, group V [KO:K01047] [EC:3.1.1.4]
18782  Pla2g2d; phospholipase A2, group IID [KO:K01047] [EC:3.1.1.4]
26970  Pla2g2e; phospholipase A2, group IIE [KO:K01047] [EC:3.1.1.4]
66350  Pla2g12a; phospholipase A2, group XIIA [KO:K01047] [EC:3.1.1.4]
69836  Pla2g12b; phospholipase A2, group XIIB [KO:K01047] [EC:3.1.1.4]
26565  Pla2g10; phospholipase A2, group X [KO:K01047] [EC:3.1.1.4]
18780  Pla2g2a; phospholipase A2, group IIA (platelets, synovial fluid) [KO:K01047] [EC:3.1.1.4]
237625  Pla2g3; phospholipase A2, group III [KO:K01047] [EC:3.1.1.4]
329502  Pla2g4e; phospholipase A2, group IVE [KO:K16342] [EC:3.1.1.4]
18783  Pla2g4a; phospholipase A2, group IVA (cytosolic, calcium-dependent) [KO:K16342] [EC:3.1.1.4]
211429  Pla2g4b; phospholipase A2, group IVB (cytosolic) [KO:K16342] [EC:3.1.1.4]
232889  Pla2g4c; phospholipase A2, group IVC (cytosolic, calcium-independent) [KO:K16342] [EC:3.1.1.4]
78390  Pla2g4d; phospholipase A2, group IVD [KO:K16342] [EC:3.1.1.4]
271844  Pla2g4f; phospholipase A2, group IVF [KO:K16342] [EC:3.1.1.4]
53357  Pla2g6; phospholipase A2, group VI [KO:K16343] [EC:3.1.1.4]
665270  Plb1; phospholipase B1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
225845  Plaat3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
270084  Lpcat2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
210992  Lpcat1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
70902  Lpcat2b; lysophosphatidylcholine acyltransferase 2B [KO:K13510] [EC:2.3.1.23 2.3.1.67]
99010  Lpcat4; lysophosphatidylcholine acyltransferase 4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
14792  Lpcat3; lysophosphatidylcholine acyltransferase 3 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
18777  Lypla1; lysophospholipase 1 [KO:K06128] [EC:3.1.1.5]
192654  Pla2g15; phospholipase A2, group XV [KO:K06129] [EC:3.1.1.5]
26394  Lypla2; lysophospholipase 2 [KO:K06130] [EC:3.1.1.5]
50767  Pnpla6; patatin-like phospholipase domain containing 6 [KO:K14676] [EC:3.1.1.5]
241274  Pnpla7; patatin-like phospholipase domain containing 7 [KO:K14676] [EC:3.1.1.5]
74182  Gpcpd1; glycerophosphocholine phosphodiesterase 1 [KO:K18695] [EC:3.1.4.2]
12647  Chat; choline acetyltransferase [KO:K00623] [EC:2.3.1.6]
11423  Ache; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
12660  Chka; choline kinase alpha [KO:K14156] [EC:2.7.1.32 2.7.1.82]
12651  Chkb; choline kinase beta [KO:K14156] [EC:2.7.1.32 2.7.1.82]
237928  Phospho1; phosphatase, orphan 1 [KO:K06124] [EC:3.1.3.75]
13026  Pcyt1a; phosphate cytidylyltransferase 1, choline, alpha isoform [KO:K00968] [EC:2.7.7.15]
236899  Pcyt1b; phosphate cytidylyltransferase 1, choline, beta isoform [KO:K00968] [EC:2.7.7.15]
28042  Selenoi; selenoprotein I [KO:K00993] [EC:2.7.8.1]
75320  Etnk1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
214253  Etnk2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
68671  Pcyt2; phosphate cytidylyltransferase 2, ethanolamine [KO:K00967] [EC:2.7.7.14]
71760  Etnppl; ethanolamine phosphate phospholyase [KO:K14286] [EC:4.2.3.2]
18618  Pemt; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
74596  Cds1; CDP-diacylglycerol synthase 1 [KO:K00981] [EC:2.7.7.41]
110911  Cds2; CDP-diacylglycerol synthase 2 [KO:K00981] [EC:2.7.7.41]
85031  Pla1a; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
19210  Ptdss1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
27388  Ptdss2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
320951  Pisd; phosphatidylserine decarboxylase [KO:K01613] [EC:4.1.1.65]
74451  Pgs1; phosphatidylglycerophosphate synthase 1 [KO:K00995] [EC:2.7.8.5]
66586  Crls1; cardiolipin synthase 1 [KO:K08744] [EC:2.7.8.41]
66826  Tafazzin; tafazzin, phospholipid-lysophospholipid transacylase [KO:K13511] [EC:2.3.1.-]
226856  Lpgat1; lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
52858  Cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
77582  Mboat7; membrane bound O-acyltransferase domain containing 7 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
mmu00010  Glycolysis / Gluconeogenesis
mmu00260  Glycine, serine and threonine metabolism
mmu00561  Glycerolipid metabolism
mmu00562  Inositol phosphate metabolism
mmu00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
mmu00565  Ether lipid metabolism
mmu00620  Pyruvate metabolism
KO pathway
ko00564   
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