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Search for EBI-366083

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		Cross Intra
9606	Homo sapiens	2176	1996
10090	Mus musculus	50	0
1891767	sv40	25	0
559292	Saccharomyces cerevisiae	15	0
11105	Hepatitis C virus genotype 1b (isolate BK)	9	0
333760	Human papillomavirus type 16	8	0
10116	Rattus norvegicus (Rat)	6	0
10970	Rotavirus sp.	6	0
333761	Human papillomavirus type 18	6	0
-2	Chemical synthesis (Chemical synthesis)	5	0
31647	Hepatitis C virus subtype 1b	4	0
8355	Xenopus laevis (African clawed frog)	4	0
10580	Human papillomavirus type 11	3	0
10588	Human papillomavirus type 39	2	0
1392	Bacillus anthracis	2	0
2697049	SARS-CoV-2	2	0
632	Yersinia pestis	2	0
63746	Hepatitis C virus genotype 1a (isolate H77)	2	0
694009	Human SARS coronavirus	2	0
9913	Bos taurus (Bovine)	2	0
-1	In vitro	1	0
10515	Human adenovirus C serotype 2 (HAdV-2)	1	0
10579	Human papillomavirus type 8	1	0
10583	Human papillomavirus type 1a	1	0
10585	Human papillomavirus type 31	1	0
10586	Human papillomavirus type 33	1	0
10614	Human papillomavirus type 3	1	0
10621	Human papillomavirus type 9	1	0
10632	JC polyomavirus	1	0
11295	Rabies virus (strain ERA)	1	0
1263720	Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)	1	0
132487	Measles virus (strain Edmonston-Schwarz vaccine)	1	0
177416	Francisella tularensis subsp. tularensis	1	0
216597	Salmonella typhimurium (strain SL1344)	1	0
243274	Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)	1	0
272561	chltr	1	0
28285	Human adenovirus C serotype 5 (HAdV-5)	1	0
31552	Human papillomavirus type 6	1	0
333284	Hepatitis C virus genotype 1b (isolate Con1) (HCV)	1	0
333763	Human papillomavirus type 32	1	0
333923	hpv05	1	0
480019	Influenza A virus (A/Moscow/10/1999(H3N2))	1	0
480116	Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979)	1	0
83333	Escherichia coli (strain K12)	1	0

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Select	Molecule A	Molecule B	Identifier A	Identifier B	Type A	Type B	Species A	Species B	Host Organism	Positive interaction	Detection Method	Publication IDs	Interaction Type	Interaction AC	Confidence Value	Expansion Method	Aliases A	Aliases B	Feature count	Interaction Annotations

Select	Molecule A	Molecule B	Identifier A	Identifier B	Type A	Type B	Species A	Species B	Host Organism	Positive interaction	Detection Method	Publication IDs	Interaction Type	Interaction AC	Confidence Value	Expansion Method	Aliases A	Aliases B	Feature count	Interaction Annotations
Show details of EBI-6974073	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	Unknown	✔️	pull down	10196247	physical association	EBI-6974073	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	0	comment homomint figure legend f5 comment mint
Show details of EBI-847717	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	anti bait coip	12915590	association	EBI-847717	MI Score:1.0	spoke expansion	gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	0
Show details of EBI-7085448	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	spr	10.1126/science.1092472 14704432	direct interaction	EBI-7085448	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	4	comment homomint kinetics IC50 = 100-300 nanomolar comment Cis-imidazoline analogs named Nutlins inhibits MDM2-p53 binding remark-internal Sh2 comment mint figure legend f1a
Show details of EBI-626521	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens U2OS osteosarcoma cell	✔️	anti bait coip	15144954	association	EBI-626521	MI Score:1.0	spoke expansion	gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	0	stimulant MDM2-NPM1 interaction is stimulated by transfection with Kaposi's sarcoma virus cyclin homolog (cyclin K). inhibition NPM1 negatively regulates the MDM2-TP53 interaction.
Show details of EBI-7598574	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens RAJI Burkitt lymphoma cell	✔️	anti bait coip	10.1016/j.febslet.2005.03.026 15848166	physical association	EBI-7598574	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	0	comment homomint remark-internal FEBS-Letters comment mint comment BIOSOURCE= Raji cells figure legend f4a
Show details of EBI-15565530	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	peptide array	16432196 10.1073/pnas.0510343103	direct interaction	EBI-15565530	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	14
Show details of EBI-15565596	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	fluorescence spectr	16432196 10.1073/pnas.0510343103	direct interaction	EBI-15565596	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	6
Show details of EBI-15565652	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	fluorescence spectr	16432196 10.1073/pnas.0510343103	direct interaction	EBI-15565652	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	2
Show details of EBI-15565575	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	itc	16432196 10.1073/pnas.0510343103	direct interaction	EBI-15565575	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	2
Show details of EBI-15565673	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	nmr	16432196 10.1073/pnas.0510343103	direct interaction	EBI-15565673	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	5
Show details of EBI-15565625	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	solution sedimentati	16432196 10.1073/pnas.0510343103	direct interaction	EBI-15565625	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	5
Show details of EBI-992074	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens HCT116 colon carcinoma cell	✔️	anti bait coip	16845383	association	EBI-992074	MI Score:1.0	spoke expansion	gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	0	figure legend 2 A and S5 E comment The interaction between Mdm2 and Daxx without p53 was shown in p53-negative HCT116 cells. Thus the interaction takes place regardless of p53 status. source-text Using a coimmunoprecipitation assay, the interaction between endogenous Daxx and Mdm2 was detected in several of the human cell lines examined, regardless of the status of p53
Show details of EBI-992896	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens U2OS osteosarcoma cell	✔️	anti bait coip	16845383	association	EBI-992896	MI Score:1.0	spoke expansion	gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	0	figure legend S2 A and S3 A comment Hausp does not affect this interaction as show when U2OS cells were transfected with a Hausp-specific siRNA or a control siRNA. source-text Using a coimmunoprecipitation assay, the interaction between endogenous Daxx and Mdm2 was detected in several of the human cell lines examined, regardless of the status of p53
Show details of EBI-7145586	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	pull down	10.1038/sj.emboj.7601435 17139261	physical association	EBI-7145586	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 author assigned name MDM2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 author assigned name p53 gene name synonym Tumor suppressor p53	1	comment homomint remark-internal EMBO-Journal figure legend f2c comment mint
Show details of EBI-7244492	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens RKO colorectal carcinoma cell	✔️	anti bait coip	10.1038/sj.emboj.7601560 17268548	physical association	EBI-7244492	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	0	comment homomint remark-internal EMBO-Journal comment mint figure legend f2b
Show details of EBI-1381306	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens U2OS osteosarcoma cell	✔️	anti bait coip	17310983	association	EBI-1381306	MI Score:1.0	spoke expansion	gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	0	figure legend 3 D agonist Actinomycin D (CHEBI:27666) source-text We also observed binding between MDM2 and p53 and between MDM2 and S7 when cells were exposed to low concentrations of actinomycin D (Act D) (5nM), which disrupts ribosomal biogenesis (Figure 3d). This likely results from the formation of a ternary complex among S7, MDM2 and p53 following the release of S7 in response to ribosomal stress.
Show details of EBI-1540086	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	pull down	17875722	physical association	EBI-1540086	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	3	inhibition Nutlin - This interaction was inhibited by Nutlin. Inhibition increased with concentration of Nutlin. source-text pDI also inhibited GST-p53 capture of in vitro translated MDM2 and MDMX with different efficiency figure legend 1 C, D inhibition pDI random peptide - This interaction was inhibited with IC50 by pDI random 12-mer peptide (LTFEHYWAQLTS).
Show details of EBI-1540050	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	elisa	17875722	physical association	EBI-1540050	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	2	inhibition 12/1 - This interaction was inhibited with IC50 0.15 micromol/L by 12/1 (MPRFMDYWEGLN). inhibition p53pep - This interaction was inhibited with IC50 3.0 micromol/L by p53pep (QETFSDLWKLLP). source-text In an ELISA assay, pDI inhibited MDM2-p53 and MDMX-p53 interactions with IC50 of 10 and 100 nmol/L respectively, comment Mutation of three key hydrophobic residues in pDI to alanine abrogated the inhibition of complex formation by pDI, suggesting pDI mimics p53 binding to MDM2. inhibition Nutlin - This interaction was inhibited with IC50 0.60 micromol/L by Nutlin. figure legend 1 A inhibition pDI random peptide - This interaction was inhibited with IC50 of 10 nmol/L by pDI random 12-mer peptide (LTFEHYWAQLTS).
Show details of EBI-15678375	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens	✔️	anti bait coip	18172499 10.1038/nature06412	association	EBI-15678375	MI Score:1.0	spoke expansion	gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	0
Show details of EBI-7833215	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens MCF-7 mammary adenocarcinoma cell	✔️	anti bait coip	10.1038/emboj.2008.25 18309296	association	EBI-7833215	MI Score:1.0	spoke expansion	gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 author assigned name MDM2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 author assigned name p53 gene name synonym Tumor suppressor p53	0	comment homomint comment mint figure legend f4a
Show details of EBI-7833501	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	pull down	10.1038/emboj.2008.25 18309296	physical association	EBI-7833501	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 author assigned name MDM2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 author assigned name p53 gene name synonym Tumor suppressor p53	1	comment homomint source-text Interaction is stronger if also PA28gamma is present in the reaction. figure legend f4e comment mint
Show details of EBI-7833585	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	molecular sieving	10.1038/emboj.2008.25 18309296	association	EBI-7833585	MI Score:1.0	spoke expansion	gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 author assigned name MDM2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 author assigned name p53 gene name synonym Tumor suppressor p53	2	comment homomint figure legend f4g comment mint
Show details of EBI-1800124	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	pull down	18485870	direct interaction	EBI-1800124	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	1	inhibition Acetylation of TP53 inhibited this interaction figure legend Fig. 5E comment An interaction between MDM4 and TP53 was also demonstrated but the source of MDM4 could not be traced. source-text More importantly, to examine the effect of acetylation in this interaction, we performed similar GST-pulldown assays with either purified unacetylated p53 or acetylated p53 proteins.
Show details of EBI-8529540	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	Cercopithecus aethiops simian cells transformed with SV40	✔️	anti tag coip	19098711 10.1038/embor.2008.231	physical association	EBI-8529540	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2 author assigned name Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 author assigned name p53 gene name synonym Tumor suppressor p53	2	comment homomint figure legend sf3a comment mint
Show details of EBI-8529558	MDM2	TP53	UniProt Q00987	UniProt P04637	protein	protein	Homo sapiens	Homo sapiens	Cercopithecus aethiops simian cells transformed with SV40	✔️	anti tag coip	19098711 10.1038/embor.2008.231	physical association	EBI-8529558	MI Score:1.0		gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2 author assigned name Mdm2	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 author assigned name p53 gene name synonym Tumor suppressor p53	2	comment homomint figure legend sf3a comment mint

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Accession	Name	Preferred ID	Type	Species	Description	Alias	Alternative IDs	Interactions found in current search	Total interactions in all IntAct
EBI-366083	TP53	UniProt P04637	protein	Homo sapiens	Cellular tumor antigen p53	gene name TP53 gene name synonym Antigen NY-CO-13 gene name synonym P53 gene name synonym Phosphoprotein p53 gene name synonym Tumor suppressor p53	UniProt27 P04637 Q16808 Q16809 Q9NP68 Q16807 Q9UBI2 Q86UG1 Q15088 Q8J016 Q15087 Q15086 Q2XN98 Q16535 Q99659 Q3LRW2 Q3LRW4 Q9BTM4 Q9NZD0 Q3LRW1 Q3LRW5 Q16810 Q9HAQ8 Q9UQ61 Q3LRW3 Q16811 Q16848 Q9NPJ2 IntAct2 EBI-366083 EBI-28980681 Ensembl6 ENSP00000391478.2 ENSP00000269305.4 ENSP00000426252.2 ENSP00000424104.2 ENSP00000519626.1 ENSP00000519624.1	2176	2181
EBI-77642	TP53BP2	UniProt Q13625	protein	Homo sapiens	Apoptosis-stimulating of p53 protein 2	gene name synonym Bcl2-binding protein gene name synonym Tumor suppressor p53-binding protein 2 gene name synonym BBP gene name synonym ASPP2 gene name synonym Renal carcinoma antigen NY-REN-51 gene name TP53BP2	IntAct1 EBI-77642 UniProt5 B4DG66 Q13625 Q86X75 Q12892 Q96KQ3	9	271
EBI-8022649	TP53BP1	UniProt Q12888-1	protein	Homo sapiens	TP53-binding protein 1	gene name TP53BP1	IntAct2 EBI-8022649 MINT-4852811 Ensembl1 ENSP00000263801.3 UniProt1 Q12888-1	17	34
EBI-617403	PLCG2	UniProt P16885	protein	Homo sapiens	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	gene name synonym Phospholipase C-IV gene name synonym Phosphoinositide phospholipase C-gamma-2 gene name PLCG2 gene name synonym Phospholipase C-gamma-2	UniProt5 Q3ZTS2 D3DUL3 Q969T5 P16885 Q59H45 Ensembl1 ENSP00000482457.1 IntAct1 EBI-617403	2	132
EBI-886	CRK	UniProt P46108	protein	Homo sapiens	Adapter molecule crk	gene name synonym Proto-oncogene c-Crk gene name synonym P38 gene name CRK	UniProt6 D3DTH6 Q96GA9 B0LPE8 A8MWE8 P46108 Q96HJ0 IntAct3 EBI-28974221 EBI-886 EBI-16429791 Ensembl1 ENSP00000300574.2	1	586
EBI-477430	KAT2B	UniProt Q92831	protein	Homo sapiens	Histone acetyltransferase KAT2B	gene name KAT2B gene name synonym Histone acetyltransferase PCAF gene name synonym P300/CBP-associated factor gene name synonym PCAF gene name synonym Lysine acetyltransferase 2B gene name synonym Spermidine acetyltransferase KAT2B	IntAct1 EBI-477430 UniProt2 Q6NSK1 Q92831 Ensembl1 ENSP00000263754.4	2	176
EBI-389739	NFYA	UniProt P23511	protein	Homo sapiens	Nuclear transcription factor Y subunit alpha	gene name synonym CAAT box DNA-binding protein subunit A gene name NFYA gene name synonym Nuclear transcription factor Y subunit A	UniProt2 Q8IXU0 P23511 Ensembl1 ENSP00000345702.6 IntAct1 EBI-389739	11	76
EBI-389728	NFYB	UniProt P25208	protein	Homo sapiens	Nuclear transcription factor Y subunit beta	gene name NFYB gene name synonym Nuclear transcription factor Y subunit B gene name synonym CAAT box DNA-binding protein subunit B gene name synonym HAP3	UniProt3 P25208 Q96IY8 A8K7B9 Ensembl2 ENSP00000240055.3 ENSP00000447486.1 IntAct1 EBI-389728	6	83
EBI-396540	TP53BP1	UniProt Q12888	protein	Homo sapiens	TP53-binding protein 1	gene name TP53BP1	UniProt6 Q7Z3U4 Q5FWZ3 F8VY86 Q4LE46 Q12888 Q2M1Z7 IntAct1 EBI-396540 Ensembl1 ENSP00000263801.3	8	601
EBI-301834	HDAC1	UniProt Q13547	protein	Homo sapiens	Histone deacetylase 1	gene name synonym Protein deacetylase HDAC1 gene name HDAC1 gene name synonym Protein deacylase HDAC1 gene name synonym RPD3L1	Ensembl1 ENSP00000362649.3 UniProt2 Q92534 Q13547 IntAct1 EBI-301834	8	1348
EBI-81215	CREBBP	UniProt Q92793	protein	Homo sapiens	CREB-binding protein	gene name CREBBP gene name synonym CBP gene name synonym Protein-lysine acetyltransferase CREBBP gene name synonym Histone lysine acetyltransferase CREBBP gene name synonym Protein lactyltransferas CREBBP	Ensembl1 ENSP00000262367.5 UniProt5 Q16376 Q4LE28 D3DUC9 Q92793 O00147 IntAct1 EBI-81215	17	319
EBI-80830	NCOR2	UniProt Q9Y618	protein	Homo sapiens	Nuclear receptor corepressor 2	gene name NCOR2 gene name synonym SMAP270 gene name synonym CTG26 gene name synonym Thyroid-, retinoic-acid-receptor-associated corepressor gene name synonym T3 receptor-associating factor gene name synonym CTG repeat protein 26 gene name synonym Silencing mediator of retinoic acid and thyroid hormone receptor	UniProt8 Q13354 Q59GM0 Q9Y618 O15416 O15421 Q56D06 O00613 Q9Y5U0 Ensembl1 ENSP00000384018.1 IntAct2 EBI-28976851 EBI-80830	7	249
EBI-2889252	NABP1	UniProt Q96AH0	protein	Homo sapiens	SOSS complex subunit B2	gene name synonym Nucleic acid-binding protein 1 gene name synonym SSB2 gene name synonym Sensor of ssDNA subunit B2 gene name synonym OBFC2A gene name synonym Single-stranded DNA-binding protein 2 gene name NABP1 gene name synonym Sensor of single-strand DNA complex subunit B2 gene name synonym Oligonucleotide/oligosaccharide-binding fold-containing protein 2A	IntAct1 EBI-2889252 Ensembl4 ENSP00000501415.1 ENSP00000403683.2 ENSP00000501487.1 ENSP00000501340.1 UniProt3 Q658Y8 Q9H5X6 Q96AH0	1	50
EBI-10827348	NEIL3	UniProt Q8TAT5	protein	Homo sapiens	Endonuclease 8-like 3	gene name synonym Nei-like protein 3 gene name synonym DNA glycosylase/AP lyase Neil3 gene name NEIL3 gene name synonym DNA glycosylase FPG2 gene name synonym Endonuclease VIII-like 3	UniProt4 Q2PPJ3 Q9NV95 Q8NG51 Q8TAT5 Ensembl1 ENSP00000264596.3 IntAct1 EBI-10827348	1	33
EBI-10827384	PADI1	UniProt Q9ULC6	protein	Homo sapiens	Protein-arginine deiminase type-1	gene name synonym Protein-arginine deiminase type I gene name PADI1 gene name synonym PAD1 gene name synonym PDI1 gene name synonym Peptidylarginine deiminase I	UniProt3 Q9ULC6 A1L4K6 Q70SX6 IntAct1 EBI-10827384 Ensembl2 ENSP00000364620.4 ENSP00000485803.1	1	5
EBI-10827421	TOP1MT	UniProt Q969P6	protein	Homo sapiens	DNA topoisomerase I, mitochondrial	gene name TOP1MT	UniProt5 Q86ST4 Q969P6 Q86V82 E7ES89 B7ZAR5 Ensembl1 ENSP00000328835.3 IntAct1 EBI-10827421	1	6
EBI-765538	YY1	UniProt P25490	protein	Homo sapiens	Transcriptional repressor protein YY1	gene name synonym NF-E1 gene name synonym Delta transcription factor gene name synonym INO80S gene name synonym Yin and yang 1 gene name synonym INO80 complex subunit S gene name Yy1	IntAct1 EBI-765538 UniProt2 Q14935 P25490 Ensembl1 ENSP00000262238.4	1	515
EBI-10827481	YY2	UniProt O15391	protein	Homo sapiens	Transcription factor YY2	gene name synonym ZNF631 gene name synonym Yin and yang 2 gene name synonym Zinc finger protein 631 gene name YY2	IntAct1 EBI-10827481 Ensembl1 ENSP00000389381.2 UniProt3 B2RP10 Q6Q1S4 O15391	1	12
EBI-10827509	ZIC3	UniProt O60481	protein	Homo sapiens	Zinc finger protein ZIC 3	gene name synonym Zinc finger protein 203 gene name synonym ZNF203 gene name ZIC3 gene name synonym Zinc finger protein of the cerebellum 3	UniProt4 Q5JY75 O60481 Q14DE5 B2CNW4 Ensembl1 ENSP00000287538.5 IntAct2 EBI-10827509 EBI-28966759	1	48
EBI-1040141	SMAD2	UniProt Q15796	protein	Homo sapiens	Mothers against decapentaplegic homolog 2	gene name synonym JV18-1 gene name synonym SMAD family member 2 gene name synonym MADH2 gene name synonym Mad-related protein 2 gene name synonym MADR2 gene name SMAD2	Ensembl2 ENSP00000262160.6 ENSP00000384449.1 UniProt1 Q15796 IntAct1 EBI-1040141	7	381
EBI-765407	BCL6	UniProt P41182	protein	Homo sapiens	B-cell lymphoma 6 protein	gene name synonym B-cell lymphoma 5 protein gene name synonym Zinc finger and BTB domain-containing protein 27 gene name synonym Zinc finger protein 51 gene name BCL6 gene name synonym ZBTB27 gene name synonym Protein LAZ-3 gene name synonym BCL5 gene name synonym ZNF51 gene name synonym LAZ3	IntAct1 EBI-765407 Ensembl2 ENSP00000384371.2 ENSP00000232014.4 UniProt4 P41182 D3DNV5 A7E241 B8PSA7	1	256
EBI-1055671	SMYD2	UniProt Q9NRG4	protein	Homo sapiens	N-lysine methyltransferase SMYD2	gene name synonym SET and MYND domain-containing protein 2 gene name synonym HSKM-B gene name synonym KMT3C gene name synonym Histone methyltransferase SMYD2 gene name SMYD2 gene name synonym Lysine N-methyltransferase 3C	Ensembl1 ENSP00000355924.5 UniProt6 B2R9P9 Q9NRG4 Q4V765 Q5VSH9 Q96AI4 I6L9H7 IntAct1 EBI-1055671	6	102
EBI-389668	MDM2	UniProt Q00987	protein	Homo sapiens	E3 ubiquitin-protein ligase Mdm2	gene name synonym Double minute 2 protein gene name synonym Oncoprotein Mdm2 gene name synonym RING-type E3 ubiquitin transferase Mdm2 gene name MDM2 gene name synonym p53-binding protein Mdm2	UniProt15 Q13226 Q8WYJ1 A8K2S6 Q8WYJ2 Q13301 Q00987 Q9UGI3 Q13300 Q9UMT8 Q13297 Q71TW9 Q13298 Q53XW0 A6NL51 Q13299 IntAct2 EBI-389668 EBI-28980679 Ensembl1 ENSP00000444430.2	120	760
EBI-352588	SMARCA5	UniProt O60264	protein	Homo sapiens	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5	gene name synonym Sucrose nonfermenting protein 2 homolog gene name synonym SNF2H gene name synonym WCRF135 gene name SMARCA5	Ensembl1 ENSP00000283131.3 UniProt1 O60264 IntAct1 EBI-352588	1	210
EBI-533224	TCF4	UniProt P15884	protein	Homo sapiens	Transcription factor 4	gene name synonym Class B basic helix-loop-helix protein 19 gene name synonym SL3-3 enhancer factor 2 gene name synonym Immunoglobulin transcription factor 2 gene name TCF4 gene name synonym BHLHB19 gene name synonym ITF2 gene name synonym SEF2	UniProt24 G0LNU1 G0LNV2 P15884 G0LNU2 G0LNV0 Q08AP3 Q08AP2 G0LNU0 G0LNU8 G0LNV1 H3BPQ1 G0LNU5 B7Z5M6 G0LNU4 B4DT37 B3KUC0 Q15439 G0LNT9 G0LNU9 Q15441 Q15440 B7Z6Y1 B3KT62 B4DUG3 IntAct1 EBI-533224 Ensembl2 ENSP00000457649.1 ENSP00000348374.4	2	706

Showing 1 to 25 of 920 entries

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physical association	853
association	647
direct interaction	288
proximity	288
colocalization	38
phosphorylation	23
methylation	9
ubiquitination	7
acetylation	5
covalent binding	4
deacetylation	3
dephosphorylation	3
hydroxylation	3
deubiquitination	2
adp ribosylation	1
neddylation	1
demethylation	1

anti tag coip	452
anti bait coip	428
pull down	251
bret	239
ch-ip	76
two hybrid pooling	75
2 hybrid	52
fps	48
tap	46
nmr	42
affinity chrom	36
two hybrid array	31
pla	29
itc	23
fluorescence imaging	20
protein kinase assay	20
proximity-dependent biotin identification	19
x-ray diffraction	19
chip-chip	18
crosslink	18
validated two hybrid	18
coip	17
molecular sieving	17
split luciferase complementation	17
confocal microscopy	14
fluorescence spectr	11
elisa	8
methyltransferase as	8
deacetylase assay	7
far western blotting	7
ubiquitinase assay	7
acetylase assay	6
comigration in sds	6
experimental interac	6
imaging technique	6
phage display	5
spr	5
emsa	4
emsa supershift	4
enzymatic study	4
peptide array	4
bfg-2h	3
competition binding	3
hydroxylase assay	3
phosphatase assay	3
solid phase assay	3
solution sedimentati	3
antibody array	2
display technology	2
filter binding	2
light scattering	2
lumier	2
ms of complexes	2
radiolabeled methyl	2
saxs	2
tem	2
ub reconstruction	2
atomic force microsc	1
bifc	1
biochemical	1
biophysical	1
chromatography	1
comig non denat gel	1
comigration in gel	1
cosedimentation	1
demethylase assay	1
electron microscopy	1
fret	1
mst	1
protein three hybrid	1
socioaffinity inference	1
two hybrid prey pooling approach	1

In vitro	518
Homo sapiens HEK293T embryonic kidney cell	355
Homo sapiens H199 lung lymph node carcinoma cell	174
Saccharomyces cerevisiae (Baker's yeast)	169
Homo sapiens	127
Homo sapiens HEK293 embryonic kidney cell	90
Homo sapiens U2OS osteosarcoma cell	86
Homo sapiens MCF-7 mammary adenocarcinoma cell	73
Homo sapiens HCT116 colon carcinoma cell	69
Homo sapiens HeLa epitheloid cervical carcinoma cell	53
Homo sapiens SKBR3 breast cancer cell	42
Homo sapiens MDA-MB-231 breast adenocarcinoma cell	40
Homo sapiens HEK293flp-in embryonic kidney cell	37
Homo sapiens Het1A oesophageal squamous cell	27
Saccharomyces cerevisiae	24
Mus musculus embryonic fibroblasts	22
Homo sapiens CAL-33 tongue squamous carcinoma cell	19
Unknown	17
Homo sapiens A549 lung carcinoma cell	17
Homo sapiens HEK293flp-in T-REX embryonic kidney cell	13
in vivo	12
Cercopithecus aethiops simian cells transformed with SV40	11
Homo sapiens HepG2 hepatocellular carcinoma cell	9
Mus musculus	8
Escherichia coli	8
Spodoptera frugiperda insect cells	7
Homo sapiens MCF10a non-transformed breast epithelial cell	7
Homo sapiens SAOS-2 osteosarcoma cell	7
Homo sapiens SCC-25 tongue squamous carcinoma cell	7
Homo sapiens BJ foreskin fibroblast cell	6
Homo sapiens ML-1 myeloblastic leukemia cell	5
Homo sapiens RKO colorectal carcinoma cell	5
Homo sapiens SH-SY5Y cell	5
Homo sapiens T47D breast cancer tumour epithelial cell	5
Homo sapiens bronchial epithelium	5
Homo sapiens CNE-2 nasopharyngeal carcinoma cell	4
Homo sapiens HT1080 fibrosarcoma cell	4
Homo sapiens Werner Syndrom (WS) cell	4
Homo sapiens colon	4
Mesocricetus auratus baby kidney cell line BHK	3
Homo sapiens AT3ABR lymphoblastoid cell	3
Homo sapiens BT-474 breast ductal carcinoma cell	3
Homo sapiens C3ABR lymphoblastoid cell	3
Mus musculus Swiss NIH 3t3 embryo fibroblast cells	2
Homo sapiens AC16 cardiomyocyte cell	2
Homo sapiens CACO2 Caucasian colon adenocarcinoma cell	2
Homo sapiens CFBE41o- cystic fibrosis bronchial epithelial cell	2
Homo sapiens Daudi Burkitt's B-cell lymphona cell	2
Homo sapiens EU-1 leukemia cell	2
Homo sapiens HT-29 colorectal adenocarcinoma cell	2
Homo sapiens HaCaT keratinocyte cell	2
Homo sapiens Hep3B hepatocellular carcinoma cell	2
Homo sapiens Huh7 hepatoma cell	2
Homo sapiens MOLT-4 T-cell leukaemia cell	2
Homo sapiens PC3 Caucasian prostate adenocarcinoma cell	2
Homo sapiens RAJI Burkitt lymphoma cell	2
Homo sapiens WI-38 fetal lung diploid fibroblast cell	2
Homo sapiens endometrial stroma	2
Homo sapiens mammary epithelium	2
Mouse D3 spindle cells	1
Mus musculus embryonic stem cell	1
African green monkey kidney cell line	1
Chlorocebus aethiops COS-1 cells	1
Homo sapiens 22rv1 cell	1
Homo sapiens A375 malignant melanoma cell	1
Homo sapiens A375P melanoma cell	1
Homo sapiens Ad12E1HER2 embryonic retinoblasts cell	1
Homo sapiens C33A epitheloid cervical carcinoma cell	1
Homo sapiens DU145 prostate cancer cell	1
Homo sapiens GM03318 fibroblast cell	1
Homo sapiens HEK293A embryonic kidney cell	1
Homo sapiens IGR-37 melanoma cell	1
Homo sapiens IMR-32 neuroblastoma cell	1
Homo sapiens Jurkat T-cell leukemia cell	1
Homo sapiens LAN-5 neuroblastoma cell	1
Homo sapiens LN-428 glioblastoma cell	1
Homo sapiens LNCaP caucasian prostate adenocarcinoma cell	1
Homo sapiens M1 fibroblast cell	1
Homo sapiens MCF-7/MDD2 mammary adenocarcinoma cell	1
Homo sapiens MCF-7/MN1 mammary adenocarcinoma cell	1
Homo sapiens MCF12A mammary epithelial cell	1
Homo sapiens MDA-MB-453 breast carcinoma cell	1
Homo sapiens MM-RU melanoma cell	1
Homo sapiens Mel202 uveal melanoma cell	1
Homo sapiens Phoenix embryonic kidney cell	1
Homo sapiens RPE retinal pigment epithelium cell	1
Homo sapiens SJSA-1 osteosarcoma cell	1
Homo sapiens SK-MEL-23 melanoma cell	1
Homo sapiens SK-UT-1 uterine leiomyosarcoma cell	1
Homo sapiens SiHa cervical carcinoma cell	1
Homo sapiens WHCO6 oesophageal cancer cell	1
Homo sapiens WM115 melanoma cell	1
Homo sapiens WM278 non-metastatic melanoma cell	1
Homo sapiens diploid fibroblast	1
Homo sapiens hepatocyte cell	1
Homo sapiens liver	1

Search for EBI-366083

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protein	2176
gene	77
dna	5
small molecule	2
ss dna	2
ds dna	1