AmiGO 2: Term Details for "replicative senescence" (GO:0090399)

Accession: GO:0090399
Name: replicative senescence
Ontology: biological_process
Synonyms: None
Alternate IDs: None
Definition: The process by which normal somatic cells reach an irreversible stage of cell cycle arrest following multiple rounds of replication; this end stage is associated with marked changes in gene expression and function. This is a natural barrier to unlimited proliferation of somatic cells, and is believed to be contolled by telomere shortening. Source: PMID:23061726, PMID:17014937
Comment: None
History: See term history for GO:0090399 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to replicative senescence (excluding "regulates").; Link to all direct and indirect annotations to replicative senescence (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for replicative senescence (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
replicative senescence	is_a	cell cycle process (GO:0022402)
replicative senescence	RO:0002162	Metazoa (NCBITaxon:33208)

subject	relation	object
negative regulation of replicative senescence (GO:1904727)	RO:0002212	replicative senescence
regulation of replicative senescence (GO:1904726)	RO:0002211	replicative senescence
positive regulation of replicative senescence (GO:1904728)	RO:0002213	replicative senescence

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