AmiGO 2: Term Details for "NF-kappaB complex" (GO:0071159)

Accession: GO:0071159
Name: NF-kappaB complex
Ontology: cellular_component
Synonyms: None
Alternate IDs: None
Definition: A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression. Source: ISBN:0849327946
Comment: None
History: See term history for GO:0071159 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to NF-kappaB complex (excluding "regulates").; Link to all direct and indirect annotations to NF-kappaB complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for NF-kappaB complex (excluding "regulates").