AmiGO 2: Term Details for "pyruvate dehydrogenase complex" (GO:0045254)

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Term Information

Accession: GO:0045254
Name: pyruvate dehydrogenase complex
Ontology: cellular_component
Synonyms: pyruvate dehydrogenase complex (lipoamide)
Alternate IDs: GO:0009364
Definition: A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. Source: PMID:36863425
Comment: The catalytic activities of the individual components of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (acetyl-transferring) activity ; GO:0004739' (E1), 'dihydrolipoyllysine-residue acetyltransferase activity ; GO:0004742' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'pyruvate dehydrogenase (NAD+) activity ; GO:0034604'.
History: See term history for GO:0045254 at QuickGO
Chem. react.: None
Subset: goslim_pir
Related: Link to all genes and gene products annotated to pyruvate dehydrogenase complex (excluding "regulates").; Link to all direct and indirect annotations to pyruvate dehydrogenase complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for pyruvate dehydrogenase complex (excluding "regulates").

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GO:0008150 biological_process
GO:0008152 metabolic process
GO:0009987 cellular process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006793 phosphorus metabolic process
GO:0044238 primary metabolic process
GO:0044281 small molecule metabolic process
GO:0009058 biosynthetic process
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0006082 organic acid metabolic process
GO:0019637 organophosphate metabolic process
GO:0006796 phosphate-containing compound metabolic process
GO:0006790 sulfur compound metabolic process
GO:0043603 amide metabolic process
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0006753 nucleoside phosphate metabolic process
GO:0090407 organophosphate biosynthetic process
GO:0043436 oxoacid metabolic process
GO:0072521 purine-containing compound metabolic process
GO:0044272 sulfur compound biosynthetic process
GO:0035383 thioester metabolic process
GO:0006637 acyl-CoA metabolic process
GO:0043604 amide biosynthetic process
GO:0019752 carboxylic acid metabolic process
GO:0005575 cellular_component
GO:0003674 molecular_function
GO:1901293 nucleoside phosphate biosynthetic process
GO:0016491 oxidoreductase activity
GO:0072522 purine-containing compound biosynthetic process
GO:0035384 thioester biosynthetic process
GO:0006084 acetyl-CoA metabolic process
GO:0071616 acyl-CoA biosynthetic process
GO:0003824 catalytic activity
GO:0032787 monocarboxylic acid metabolic process
GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0032991 protein-containing complex
GO:0006085 acetyl-CoA biosynthetic process
GO:1902494 catalytic complex
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0004738 pyruvate dehydrogenase activity
GO:0006090 pyruvate metabolic process
GO:1990204 oxidoreductase complex
GO:0006086 pyruvate decarboxylation to acetyl-CoA
GO:0034603 pyruvate dehydrogenase [NAD(P)+] activity
GO:0045240 alpha-ketoacid dehydrogenase complex
GO:0034604 pyruvate dehydrogenase (NAD+) activity
GO:0045254 pyruvate dehydrogenase complex

Parents of pyruvate dehydrogenase complex (GO:0045254)

subject	relation	object
pyruvate dehydrogenase complex	RO:0002215	pyruvate dehydrogenase (NAD+) activity (GO:0034604)
pyruvate dehydrogenase complex	is_a	alpha-ketoacid dehydrogenase complex (GO:0045240)

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Wikipedia: Pyruvate_dehydrogenase_complex