AmiGO 2: Term Details for "non-canonical NF-kappaB signal transduction" (GO:0038061)

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Term Information

Accession: GO:0038061
Name: non-canonical NF-kappaB signal transduction
Ontology: biological_process
Synonyms: NIK-IKK kinase cascade, NIK-IKK signaling pathway, NIK-IKK-alpha cascade, NIK/NF-kappaB cascade, NIK/NF-kappaB signal transduction, NIK/NF-kappaB signaling, non-canonical NF-KB signaling, noncanonical NF-kappaB signaling, noncanonical nuclear factor kappaB (NF-kappaB) pathway, p52-dependent NF-kappaB signaling, NF-kappaB cascade
Alternate IDs: None
Definition: An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF). Source: GOC:signaling, PMID:15140882, GOC:vs, PMID:34659217, PMID:11239468, GOC:bf, GOC:mg2
Comment: None
History: See term history for GO:0038061 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to non-canonical NF-kappaB signal transduction (excluding "regulates").; Link to all direct and indirect annotations to non-canonical NF-kappaB signal transduction (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for non-canonical NF-kappaB signal transduction (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical entity
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0141124 intracellular signaling cassette
GO:0038061 non-canonical NF-kappaB signal transduction
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction
GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction
GO:1901222 regulation of non-canonical NF-kappaB signal transduction

Parents of non-canonical NF-kappaB signal transduction (GO:0038061)

subject	relation	object
non-canonical NF-kappaB signal transduction	is_a	intracellular signaling cassette (GO:0141124)

Children of non-canonical NF-kappaB signal transduction (GO:0038061)

subject	relation	object
negative regulation of non-canonical NF-kappaB signal transduction (GO:1901223)	RO:0002212	non-canonical NF-kappaB signal transduction
positive regulation of non-canonical NF-kappaB signal transduction (GO:1901224)	RO:0002213	non-canonical NF-kappaB signal transduction
activation of NF-kappaB-inducing kinase activity (GO:0007250)	BFO:0000050	non-canonical NF-kappaB signal transduction
regulation of non-canonical NF-kappaB signal transduction (GO:1901222)	RO:0002211	non-canonical NF-kappaB signal transduction

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