AmiGO 2: Term Details for "signaling adaptor activity" (GO:0035591)

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Term Information

Accession: GO:0035591
Name: signaling adaptor activity
Ontology: molecular_function
Synonyms: signaling protein recruiting activity, signalling adaptor activity, signaling scaffold activity
Alternate IDs: None
Definition: The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. Source: GOC:bf, PMID:19104498
Comment: A signaling adaptor can bring together both protein and non-protein molecules within a signaling pathway. Scaffold proteins act in at least four ways: tethering signaling components, localizing these components to specific areas of the cell, regulating signal transduction by coordinating positive and negative feedback signals, and insulating correct signaling proteins from competing proteins (PMID:19104498).
History: See term history for GO:0035591 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to signaling adaptor activity (excluding "regulates").; Link to all direct and indirect annotations to signaling adaptor activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for signaling adaptor activity (excluding "regulates").

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GO:0003674 molecular_function
GO:0060090 molecular adaptor activity
GO:0030674 protein-macromolecule adaptor activity
GO:0035591 signaling adaptor activity
GO:0008269 JAK pathway signal transduction adaptor activity
GO:0005078 MAP-kinase scaffold activity
GO:0030159 signaling receptor complex adaptor activity

Parents of signaling adaptor activity (GO:0035591)

subject	relation	object
signaling adaptor activity	is_a	protein-macromolecule adaptor activity (GO:0030674)

Children of signaling adaptor activity (GO:0035591)

subject	relation	object
MAP-kinase scaffold activity (GO:0005078)	is_a	signaling adaptor activity
signaling receptor complex adaptor activity (GO:0030159)	is_a	signaling adaptor activity
JAK pathway signal transduction adaptor activity (GO:0008269)	is_a	signaling adaptor activity

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