AmiGO 2: Term Details for "IkappaB kinase complex" (GO:0008385)

Notice

Some functionality on this page depends on JavaScript. To fully use the features of AmiGO 2, enable JavaScript in your browser and reload from the landing page.

Term Information

Accession: GO:0008385
Name: IkappaB kinase complex
Ontology: cellular_component
Synonyms: IKK complex, heterotrimeric IKK complex, trimeric IKK complex
Alternate IDs: None
Definition: A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. Source: GOC:bf, GOC:ma, PMID:20300203, PMID:12055104
Comment: None
History: See term history for GO:0008385 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to IkappaB kinase complex (excluding "regulates").; Link to all direct and indirect annotations to IkappaB kinase complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for IkappaB kinase complex (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

Filter results

View this term in QuickGO.

Additional external viewing options

OLSVis (interactive)

Additional internal viewing options

GO:0008150 biological_process
GO:0065007 biological regulation
GO:0009987 cellular process
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
CARO:0030000 biological entity
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0005575 cellular_component
GO:0008152 metabolic process
GO:0050794 regulation of cellular process
GO:0023052 signaling
CARO:0000000 anatomical entity
GO:0003824 catalytic activity
GO:0005622 intracellular anatomical structure
GO:0043170 macromolecule metabolic process
GO:0003674 molecular_function
GO:0006793 phosphorus metabolic process
GO:0044238 primary metabolic process
GO:0032991 protein-containing complex
GO:0007165 signal transduction
UBERON:0001062 anatomical entity
UBERON:0000061 anatomical structure
GO:1902494 catalytic complex
GO:0035556 intracellular signal transduction
GO:0043412 macromolecule modification
CARO:0000006 material anatomical entity
GO:0006796 phosphate-containing compound metabolic process
GO:0019538 protein metabolic process
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0140096 catalytic activity, acting on a protein
CL:0000000 cell
GO:0110165 cellular anatomical structure
CARO:0000003 connected anatomical structure
GO:0141124 intracellular signaling cassette
GO:0016301 kinase activity
UBERON:0000465 material anatomical entity
GO:0016310 phosphorylation
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0036211 protein modification process
GO:1990234 transferase complex
GO:0007249 canonical NF-kappaB signal transduction
GO:0004672 protein kinase activity
GO:0006468 protein phosphorylation
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:0005737 cytoplasm
GO:0007252 I-kappaB phosphorylation
GO:1902911 protein kinase complex
GO:0004674 protein serine/threonine kinase activity
GO:0005829 cytosol
GO:0008384 IkappaB kinase activity
GO:1902554 serine/threonine protein kinase complex
GO:0008385 IkappaB kinase complex

Parents of IkappaB kinase complex (GO:0008385)

subject	relation	object
IkappaB kinase complex	BFO:0000050	cytosol (GO:0005829)
IkappaB kinase complex	RO:0002215	IkappaB kinase activity (GO:0008384)
IkappaB kinase complex	is_a	serine/threonine protein kinase complex (GO:1902554)
IkappaB kinase complex	RO:0002162	cellular organisms (NCBITaxon:131567)

This term has no children.

GONUTS Add usage comments for this term on the GONUTS wiki.