AmiGO 2: Term Details for "nucleotide-excision repair" (GO:0006289)

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Term Information

Accession: GO:0006289
Name: nucleotide-excision repair
Ontology: biological_process
Synonyms: NER, pyrimidine-dimer repair, DNA damage excision, intrastrand cross-link repair
Alternate IDs: GO:0045001
Definition: A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). Source: PMID:10197977
Comment: Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair.
History: See term history for GO:0006289 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to nucleotide-excision repair (excluding "regulates").; Link to all direct and indirect annotations to nucleotide-excision repair (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for nucleotide-excision repair (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0008152 metabolic process
GO:0071704 organic substance metabolic process
GO:0009987 cellular process
GO:1901360 organic cyclic compound metabolic process
GO:0044238 primary metabolic process
GO:0050896 response to stimulus
GO:0051716 cellular response to stimulus
GO:0043170 macromolecule metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006950 response to stress
GO:0033554 cellular response to stress
GO:0090304 nucleic acid metabolic process
GO:0006974 DNA damage response
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0070911 global genome nucleotide-excision repair
GO:0000109 nucleotide-excision repair complex
GO:1901255 nucleotide-excision repair involved in interstrand cross-link repair
GO:0000715 nucleotide-excision repair, DNA damage recognition
GO:0000718 nucleotide-excision repair, DNA damage removal
GO:0000717 nucleotide-excision repair, DNA duplex unwinding
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006293 nucleotide-excision repair, preincision complex stabilization
GO:0000720 pyrimidine dimer repair by nucleotide-excision repair
GO:2000819 regulation of nucleotide-excision repair
GO:0006283 transcription-coupled nucleotide-excision repair

Parents of nucleotide-excision repair (GO:0006289)

subject	relation	object
nucleotide-excision repair	is_a	DNA repair (GO:0006281)

Children of nucleotide-excision repair (GO:0006289)

subject	relation	object
transcription-coupled nucleotide-excision repair (GO:0006283)	is_a	nucleotide-excision repair
pyrimidine dimer repair by nucleotide-excision repair (GO:0000720)	is_a	nucleotide-excision repair
regulation of nucleotide-excision repair (GO:2000819)	RO:0002211	nucleotide-excision repair
nucleotide-excision repair, preincision complex assembly (GO:0006294)	BFO:0000050	nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization (GO:0006293)	BFO:0000050	nucleotide-excision repair
nucleotide-excision repair complex (GO:0000109)	RO:0002216	nucleotide-excision repair
nucleotide-excision repair, DNA damage removal (GO:0000718)	BFO:0000050	nucleotide-excision repair
nucleotide-excision repair, DNA gap filling (GO:0006297)	BFO:0000050	nucleotide-excision repair
nucleotide-excision repair involved in interstrand cross-link repair (GO:1901255)	is_a	nucleotide-excision repair
nucleotide-excision repair, DNA damage recognition (GO:0000715)	BFO:0000050	nucleotide-excision repair
global genome nucleotide-excision repair (GO:0070911)	is_a	nucleotide-excision repair
nucleotide-excision repair, DNA duplex unwinding (GO:0000717)	BFO:0000050	nucleotide-excision repair

nucleotide-excision repair