AmiGO 2: Term Details for "toll-like receptor signaling pathway" (GO:0002224)

Term Information

Accession: GO:0002224
Name: toll-like receptor signaling pathway
Ontology: biological_process
Synonyms: TLR signaling pathway, toll-like receptor signalling pathway
Alternate IDs: None
Definition: The series of molecular signals initiated by a ligand binding to a toll-like receptor of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. Source: PMID:12467241, PMID:12524386, PMID:15585605, ISBN:0781735149, PMID:15728447, GOC:add, GO_REF:0000022, PMID:12855817
Comment: Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses.
History: See term history for GO:0002224 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to toll-like receptor signaling pathway (excluding "regulates").; Link to all direct and indirect annotations to toll-like receptor signaling pathway (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for toll-like receptor signaling pathway (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0009607 response to biotic stimulus
GO:0009605 response to external stimulus
GO:0044419 biological process involved in interspecies interaction between organisms
GO:0043207 response to external biotic stimulus
GO:0065007 biological regulation
GO:0006952 defense response
GO:0050789 regulation of biological process
GO:0048583 regulation of response to stimulus
GO:0051707 response to other organism
GO:0050896 response to stimulus
GO:0006950 response to stress
GO:0009987 cellular process
GO:0098542 defense response to other organism
GO:0002376 immune system process
GO:0048518 positive regulation of biological process
GO:0002682 regulation of immune system process
GO:0080134 regulation of response to stress
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0140546 defense response to symbiont
GO:0006955 immune response
GO:0045087 innate immune response
GO:0002684 positive regulation of immune system process
GO:0048584 positive regulation of response to stimulus
GO:0050794 regulation of cellular process
GO:0031347 regulation of defense response
GO:0050776 regulation of immune response
GO:0002831 regulation of response to biotic stimulus
GO:0032101 regulation of response to external stimulus
GO:0023052 signaling
GO:0031349 positive regulation of defense response
GO:0050778 positive regulation of immune response
GO:0002833 positive regulation of response to biotic stimulus
GO:0032103 positive regulation of response to external stimulus
GO:0045088 regulation of innate immune response
GO:0007165 signal transduction
GO:0002253 activation of immune response
GO:0002764 immune response-regulating signaling pathway
GO:0045089 positive regulation of innate immune response
GO:0002218 activation of innate immune response
GO:0002757 immune response-activating signaling pathway
GO:0002758 innate immune response-activating signaling pathway
GO:0002221 pattern recognition receptor signaling pathway
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0034123 positive regulation of toll-like receptor signaling pathway
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0035664 TIRAP-dependent toll-like receptor signaling pathway
GO:0035682 toll-like receptor 21 signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway

Parents of toll-like receptor signaling pathway (GO:0002224)

subject	relation	object
toll-like receptor signaling pathway	is_a	pattern recognition receptor signaling pathway (GO:0002221)

Children of toll-like receptor signaling pathway (GO:0002224)

subject	relation	object
negative regulation of toll-like receptor signaling pathway (GO:0034122)	RO:0002212	toll-like receptor signaling pathway
positive regulation of toll-like receptor signaling pathway (GO:0034123)	RO:0002213	toll-like receptor signaling pathway
TIRAP-dependent toll-like receptor signaling pathway (GO:0035664)	is_a	toll-like receptor signaling pathway
toll-like receptor 21 signaling pathway (GO:0035682)	is_a	toll-like receptor signaling pathway
regulation of toll-like receptor signaling pathway (GO:0034121)	RO:0002211	toll-like receptor signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway (GO:0038124)	is_a	toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway (GO:0038123)	is_a	toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway (GO:0002756)	is_a	toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway (GO:0002755)	is_a	toll-like receptor signaling pathway

toll-like receptor signaling pathway

Term Information

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Parents of toll-like receptor signaling pathway (GO:0002224)

Children of toll-like receptor signaling pathway (GO:0002224)

None.