The USP (ubiquitin-specific protease) family is a family of deubiquitinating enzymes characterized by the presence of a USP domain, which is a conserved catalytic domain. USP enzymes are cysteine proteases.
| Identifier | Name | Relation |
| FPLX:USP17L | USP17L | isa |
| FPLX:USP9 | USP9 | isa |
| FPLX:USPL | USPL | isa |
| HGNC:12607 | USP1 | isa |
| HGNC:12608 | USP10 | isa |
| HGNC:12609 | USP11 | isa |
| HGNC:12611 | USP13 | isa |
| HGNC:12612 | USP14 | isa |
| HGNC:12613 | USP15 | isa |
| HGNC:12614 | USP16 | isa |
| Relation | Identifier | Name |
| isa | FPLX:Deubiquitinase | Deubiquitinase |