Description
Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme; human homolog HMBS can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid [Source:SGD;Acc:S000002364]
Gene Synonyms
OLE2
Location
Chromosome IV: 92,762-93,745 reverse strand.
R64-1-1:BK006938.2
About this gene
This gene has 1 transcript (splice variant) and 233 orthologues.
Transcripts
