CHEBI:85994 - lenvatinib

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ChEBI Name lenvatinib
ChEBI ID CHEBI:85994
Definition A member of the class of quinolines that is the carboxamide of 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxylic acid. A multi-kinase inhibitor and orphan drug used (as its mesylate salt) for the treatment of various types of thyroid cancer that do not respond to radioiodine.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information ChemicalBook:CB12484883, eMolecules:31507658, Selleckchem:E7080, ZINC000003816292
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Formula C21H19ClN4O4
Net Charge 0
Average Mass 426.854
Monoisotopic Mass 426.10948
InChI InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)
InChIKey WOSKHXYHFSIKNG-UHFFFAOYSA-N
SMILES C=1(C(=CC2=C(C1)N=CC=C2OC3=CC(=C(C=C3)NC(NC4CC4)=O)Cl)C(N)=O)OC
Roles Classification
Biological Role(s): vascular endothelial growth factor receptor antagonist
An antagonist at the vascular endothelial growth factor receptor.
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
fibroblast growth factor receptor antagonist
An antagonist at the fibroblast growth factor receptor.
Application(s): orphan drug
Any drug that has been developed specifically for treatment of a rare medical condition, the condition itself being known as an orphan disease.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing lenvatinib (CHEBI:85994) has role antineoplastic agent (CHEBI:35610)
lenvatinib (CHEBI:85994) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
lenvatinib (CHEBI:85994) has role fibroblast growth factor receptor antagonist (CHEBI:63457)
lenvatinib (CHEBI:85994) has role orphan drug (CHEBI:71031)
lenvatinib (CHEBI:85994) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
lenvatinib (CHEBI:85994) is a aromatic amide (CHEBI:62733)
lenvatinib (CHEBI:85994) is a aromatic ether (CHEBI:35618)
lenvatinib (CHEBI:85994) is a cyclopropanes (CHEBI:51454)
lenvatinib (CHEBI:85994) is a monocarboxylic acid amide (CHEBI:29347)
lenvatinib (CHEBI:85994) is a monochlorobenzenes (CHEBI:83403)
lenvatinib (CHEBI:85994) is a phenylureas (CHEBI:134043)
lenvatinib (CHEBI:85994) is a quinolines (CHEBI:26513)
lenvatinib (CHEBI:85994) is conjugate base of lenvatinib(1+) (CHEBI:85998)
Incoming lenvatinib(1+) (CHEBI:85998) is conjugate acid of lenvatinib (CHEBI:85994)
IUPAC Name
4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide
INN Source
lenvatinib KEGG DRUG
Synonyms Sources
4-(3-Chloro-4-(N'-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide ChemIDplus
E 7080 ChemIDplus
E7080 ChemIDplus
UNII-EE083865G2 ChemIDplus
Manual Xrefs Databases
4942 DrugCentral
D09919 KEGG DRUG
Lenvatinib Wikipedia
LEV PDBeChem
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Registry Numbers Types Sources
12096874 Reaxys Registry Number Reaxys
417716-92-8 CAS Registry Number KEGG DRUG
417716-92-8 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
20 May 2017