| Prednisolone is a corticosteroid, a steroid hormone used to treat certain types of allergies, inflammatory conditions, autoimmune disorders, and cancers, electrolyte imbalances and skin conditions. Some of these conditions include adrenocortical insufficiency, high blood calcium, rheumatoid arthritis, dermatitis, eye inflammation, asthma, multiple sclerosis, and phimosis. It can be taken by mouth, injected into a vein, used topically as a skin cream, or as eye drops. It differs from the similarly named prednisone in having a hydroxyl at the 11th carbon instead of a ketone.
Common side effects with short-term use include nausea, difficulty concentrating, insomnia, increased appetite, and fatigue. More severe side effects include psychiatric problems, which may occur in about 5% of people. Common side effects with long-term use include bone loss, weakness, yeast infections, and easy bruising. While short-term use in the later part of pregnancy is safe, long-term use or use in early pregnancy is occasionally associated with harm to the baby. It is a glucocorticoid made from hydrocortisone (cortisol).
Prednisolone was discovered and approved for medical use in 1955. It is on the World Health Organization's List of Essential Medicines. It is available as a generic drug. In 2022, it was the 136th most commonly prescribed medication in the United States, with more than 4 million prescriptions. |
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InChI=1S/C21H28O5/c1- 19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 |
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| [H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO |
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environmental contaminant
Any minor or unwanted substance introduced into the environment that can have undesired effects.
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adrenergic agent
Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter.
immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
drug metabolite
xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
hormone
Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
(via steroid hormone )
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adrenergic agent
Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter.
anti-inflammatory drug
A substance that reduces or suppresses inflammation.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
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View more via ChEBI Ontology
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11β,17,21-trihydroxypregna-1,4-diene-3,20-dione
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prednisolona
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ChemIDplus
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prednisolone
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ChemIDplus
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prednisolone
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WHO MedNet
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prednisolonum
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ChemIDplus
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(11β)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione
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ChEBI
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1,4-pregnadiene-11β,17α,21-triol-3,20-dione
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ChemIDplus
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1,4-pregnadiene-3,20-dione-11β,17α,21-triol
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ChemIDplus
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3,20-dioxo-11β,17α,21-trihydroxy-1,4-pregnadiene
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ChemIDplus
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Δ1-dehydrocortisol
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ChemIDplus
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Δ1-dehydrohydrocortisone
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ChemIDplus
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Δ1-hydrocortisone
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ChemIDplus
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hydroretrocortine
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ChemIDplus
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metacortandralone
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ChemIDplus
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1354103
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Reaxys Registry Number
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Reaxys
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50-24-8
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CAS Registry Number
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KEGG COMPOUND
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50-24-8
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CAS Registry Number
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ChemIDplus
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