dorsomorphin (CHEBI:78510)

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ChEBI Name	dorsomorphin

ChEBI ID	CHEBI:78510

Definition	A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Matthias Ziehm

Supplier Information	ZINC000004632133

Download	Molfile XML SDF

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Formula

C24H25N5O

Net Charge

Average Mass

399.48820

Monoisotopic Mass

399.20591

InChI

InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2

InChIKey

XHBVYDAKJHETMP-UHFFFAOYSA-N

SMILES

C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1

Roles Classification
Biological Role(s):	EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of any [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase (EC 2.7.11.31). bone morphogenetic protein receptor antagonist An antagonist at the bone morphogenetic protein receptor.

ChEBI Ontology
Outgoing	dorsomorphin (CHEBI:78510) has role bone morphogenetic protein receptor antagonist (CHEBI:78623) dorsomorphin (CHEBI:78510) has role EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor (CHEBI:78622) dorsomorphin (CHEBI:78510) is a aromatic ether (CHEBI:35618) dorsomorphin (CHEBI:78510) is a piperidines (CHEBI:26151) dorsomorphin (CHEBI:78510) is a pyrazolopyrimidine (CHEBI:38669) dorsomorphin (CHEBI:78510) is a pyridines (CHEBI:26421)

IUPAC Name

6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine

Synonym	Source
compound C	ChEBI

Last Modified

12 April 2024