methoxyflurane (CHEBI:6843)

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ChEBI Name	methoxyflurane

ChEBI ID	CHEBI:6843

Definition	An ether in which the two groups attached to the central oxygen atom are methyl and 2,2-dichloro-1,1-difluoroethyl.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information	ZINC000012496544

Download	Molfile XML SDF

Wikipedia	License
Dicoumarol (INN) or dicumarol (USAN) is a naturally occurring anticoagulant drug that depletes stores of vitamin K (similar to warfarin, a drug that dicoumarol inspired). It is also used in biochemical experiments as an inhibitor of reductases. Dicoumarol is a natural chemical substance of combined plant and fungal origin. It is a derivative of coumarin, a bitter-tasting but sweet-smelling substance made by plants that does not itself affect coagulation, but which is (classically) transformed in mouldy feeds or silages by a number of species of fungi, into active dicoumarol. Dicoumarol does affect coagulation, and was discovered in mouldy wet sweet-clover hay, as the cause of a naturally occurring bleeding disease in cattle. See warfarin for a more detailed discovery history. Identified in 1940, dicoumarol became the prototype of the 4-hydroxycoumarin anticoagulant drug class. Dicoumarol itself, for a short time, was employed as a medicinal anticoagulant drug, but since the mid-1950s has been replaced by its simpler derivative warfarin, and other 4-hydroxycoumarin drugs. It is given orally, and it acts within two days.
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Formula

C3H4Cl2F2O

Net Charge

Average Mass

164.96600

Monoisotopic Mass

163.96073

InChI

InChI=1S/C3H4Cl2F2O/c1-8-3(6,7)2(4)5/h2H,1H3

InChIKey

RFKMCNOHBTXSMU-UHFFFAOYSA-N

SMILES

COC(F)(F)C(Cl)Cl

Roles Classification
Biological Role(s):	non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. hepatotoxic agent A role played by a chemical compound exhibiting itself through the ability to induce damage to the liver in animals. nephrotoxic agent A role played by any chemical compound (natural or synthetic) exhibiting itself through the ability to induce damage to the kidneys.

Application(s):	inhalation anaesthetic non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.

ChEBI Ontology
Outgoing	methoxyflurane (CHEBI:6843) has role hepatotoxic agent (CHEBI:50908) methoxyflurane (CHEBI:6843) has role inhalation anaesthetic (CHEBI:38870) methoxyflurane (CHEBI:6843) has role nephrotoxic agent (CHEBI:50909) methoxyflurane (CHEBI:6843) has role non-narcotic analgesic (CHEBI:35481) methoxyflurane (CHEBI:6843) is a ether (CHEBI:25698) methoxyflurane (CHEBI:6843) is a organochlorine compound (CHEBI:36683) methoxyflurane (CHEBI:6843) is a organofluorine compound (CHEBI:37143)

IUPAC Names

2,2-dichloro-1,1-difluoro-1-methoxyethane

2,2-dichloro-1,1-difluoroethyl methyl ether

Synonyms	Sources
Methoflurane	HMDB
Methoxyfluoran	HMDB
Methoxyfluran	HMDB
Methyl 1,1-difluoro-2,2-dichloroethyl ether	NIST Chemistry WebBook

Brand Name	Source
Penthrane	KEGG DRUG

Last Modified

22 February 2017