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| CHEBI:64007 |
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| An icosanoid obtained by formal epoxidation of one of the double bonds of arachidonic acid. |
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This entity has been manually annotated by the ChEBI Team.
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Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
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metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
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platelet aggregation inhibitor
A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
anti-inflammatory drug
A substance that reduces or suppresses inflammation.
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View more via ChEBI Ontology
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epoxyeicosatrienoic acid
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ChEBI
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epoxyeicosatrienoic acids
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ChEBI
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epoxyicosatrienoic acid
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ChEBI
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epoxyicosatrienoic acids
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ChEBI
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Medvedev AE, Goodwin BL, Sandler M, Glover V (1999)
Efficacy of isatin analogues as antagonists of rat brain and heart atrial natriuretic peptide receptors coupled to particulate guanylyl cyclase.
Biochemical pharmacology 57, 913-915 [PubMed:10086325]
[show Abstract]
Isatin is an endogenous indole and an inhibitor of atrial natriuretic peptide (ANP) receptors coupled with particulate guanylyl cyclase (GC). In this study, several isatin analogues were tested as inhibitors of ANP-stimulated GC in rat brain and heart membranes. None of these analogues affected activity in the absence of ANP, or stimulated ANP-induced activity. In both tissues, some 5-substituted isatins (5-hydroxyisatin, 5-methylisatin, and 5-aminoisatin) exhibited more effective inhibitory activity than isatin itself, with IC50 values in the range 1.3-20 microM. The efficacy of other analogues varied and was not consistent between the two tissues, raising the possibility of receptor heterogeneity and relative selectivity of inhibition. Some substituted isatins may have a role as pharmacological tools for investigating the physiological roles of natriuretic peptides and their receptors. |
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