CHEBI:62913 - EC 2.4.2.30 (NAD⁺ ADP-ribosyltransferase) inhibitor

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ChEBI Name EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor ChEBI ID CHEBI:62913 ChEBI ASCII Name EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor Definition An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of a NAD+ ADP-ribosyltransferase (EC 2.4.2.30). Stars This entity has been manually annotated by the ChEBI Team. Wikipedia License PARP inhibitors are a class of drugs that are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP), which plays a role in repairing DNA in damaged cells. Medical uses of these drugs include the treatment of heritable cancers. Several forms of cancer are more dependent on PARP than regular cells, making PARP (PARP1, PARP2 etc.) an attractive target for cancer therapy. PARP inhibitors appear to improve progression-free survival in women with recurrent platinum-sensitive ovarian cancer, as evidenced mainly by olaparib added to conventional treatment. In addition to their use in cancer therapy, PARP inhibitors are considered a potential treatment for acute life-threatening diseases, such as stroke and myocardial infarction, as well as for long-term neurodegenerative diseases. Read full article at Wikipedia ChEBI Ontology Outgoing EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) is a EC 2.4.2.* (pentosyltransferase) inhibitor (CHEBI:76790) Incoming 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide (CHEBI:177298) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) 2-{4-[(3R)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (CHEBI:177299) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) 3-aminobenzamide (CHEBI:64042) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) isoquinoline-1,5-diol (CHEBI:64044) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) ITK7 (CHEBI:231599) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) MC2050 (CHEBI:232977) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) mefuparib (CHEBI:167905) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) mefuparib hydrochloride (CHEBI:167899) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) nicotinamide (CHEBI:17154) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) niraparib (CHEBI:176844) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) NU 1025 (CHEBI:75399) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) olaparib (CHEBI:83766) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) phenanthridone (CHEBI:75292) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) PJ34 (CHEBI:167900) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) PJ34 hydrochloride (CHEBI:167904) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) rucaparib (CHEBI:134689) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) rucaparib camsylate (CHEBI:134692) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) veliparib (CHEBI:62880) has role EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitor (CHEBI:62913) Synonyms Sources ADP-ribosyltransferase (polymerising) inhibitor ChEBI ADP-ribosyltransferase (polymerising) inhibitors ChEBI ADP-ribosyltransferase (polymerizing) inhibitor ChEBI ADP-ribosyltransferase (polymerizing) inhibitors ChEBI EC 2.4.2.30 (NAD+ ADP-ribosyltransferase) inhibitors ChEBI EC 2.4.2.30 inhibitor ChEBI EC 2.4.2.30 inhibitors ChEBI NAD+ ADP-ribosyltransferase (EC 2.4.2.30) inhibitor ChEBI NAD+ ADP-ribosyltransferase (EC 2.4.2.30) inhibitors ChEBI NAD+ ADP-ribosyltransferase inhibitor ChEBI NAD+ ADP-ribosyltransferase inhibitors ChEBI NAD+:poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitor ChEBI NAD+:poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitors ChEBI NAD+:poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitor ChEBI NAD+:poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitors ChEBI PARP ChEBI PARPs ChEBI poly(adenosine diphosphate ribose) polymerase inhibitor ChEBI poly(adenosine diphosphate ribose) polymerase inhibitors ChEBI poly(ADP-ribose) polymerase inhibitor ChEBI poly(ADP-ribose) polymerase inhibitors ChEBI poly(ADP-ribose) synthase inhibitor ChEBI poly(ADP-ribose) synthase inhibitors ChEBI poly(ADP-ribose) synthetase inhibitor ChEBI poly(ADP-ribose) synthetase inhibitors ChEBI Manual Xref Database PARP_inhibitor Wikipedia View more database links Last Modified 19 August 2024