CHEBI:46631 - clonidine

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name clonidine
ChEBI ID CHEBI:46631
Stars This entity has been manually annotated by the ChEBI Team.
Formula C9H9Cl2N3
Net Charge 0
Average Mass 230.094
Monoisotopic Mass 229.01735
Roles Classification
Biological Role(s): sympatholytic agent
Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
alpha-adrenergic agonist
An agent that selectively binds to and activates alpha-adrenergic receptors.
Application(s): sympatholytic agent
Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
alpha-adrenergic agonist
An agent that selectively binds to and activates alpha-adrenergic receptors.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing clonidine (CHEBI:46631) has functional parent 2,6-dichloroaniline (CHEBI:46630)
clonidine (CHEBI:46631) has role α-adrenergic agonist (CHEBI:35569)
clonidine (CHEBI:46631) has role antihypertensive agent (CHEBI:35674)
clonidine (CHEBI:46631) has role non-narcotic analgesic (CHEBI:35481)
clonidine (CHEBI:46631) has role sympatholytic agent (CHEBI:66991)
clonidine (CHEBI:46631) is a dichlorobenzene (CHEBI:23697)
clonidine (CHEBI:46631) is a guanidines (CHEBI:24436)
Incoming clonidine (amino form) (CHEBI:46632) is a clonidine (CHEBI:46631)
clonidine (imino form) (CHEBI:3757) is a clonidine (CHEBI:46631)
INNs Sources
clonidina WHO MedNet
clonidine WHO MedNet
clonidine ChemIDplus
clonidinum ChEBI
Synonym Source
Clonidin ChemIDplus
Brand Names Sources
Catapres-TTS IUPHAR
Catarpres-TTS IUPHAR
Manual Xrefs Databases
DB00575 DrugBank
US3202660 Patent
View more database links
Registry Number Type Source
4205-90-7 CAS Registry Number ChemIDplus
Citations Types Sources
11682401 PubMed citation Europe PMC
15883756 PubMed citation Europe PMC
16863391 PubMed citation Europe PMC
18986614 PubMed citation Europe PMC
19328116 PubMed citation Europe PMC
21399902 PubMed citation Europe PMC
21525113 PubMed citation Europe PMC
Last Modified
22 October 2014
General Comment
2011-08-01 Clonidine is an α2-adrenergic agonist that can cross the blood-brain barrier and act in the hypothalamus to induce a decrease in blood pressure. It is used (generally as the monohydrochloride) in the management of hypertension, although other drugs with fewer side effects are normally preferred. It is also used for the treatment of migraine, and as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone.