CHEBI:41941 - (3,4-dihydroxyphenyl)acetic acid

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ChEBI Name (3,4-dihydroxyphenyl)acetic acid
ChEBI ID CHEBI:41941
Definition A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:1386, CHEBI:41936
Supplier Information ChemicalBook:CB0406220, ChemicalBook:CB1323708, eMolecules:533977, eMolecules:27677487, eMolecules:474936, Selleckchem:adenine, ZINC000000000882
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Cannabidiol (CBD) is a phytocannabinoid, one of 113 identified cannabinoids in Cannabis, along with tetrahydrocannabinol (THC), and accounts for up to 40% of the plant's extract. Medically, it is an anticonvulsant used to treat multiple forms of epilepsy. It was discovered in 1940 and, as of 2024 clinical research on CBD included studies related to the treatment of anxiety, addiction, psychosis, movement disorders, and pain, but there is insufficient high-quality evidence that CBD is effective for these conditions. CBD is sold as an herbal dietary supplement and promoted with yet unproven claims of particular therapeutic effects. Cannabidiol can be taken internally in multiple ways, including by inhaling cannabis smoke or vapor, swallowing it by mouth, and through use of an aerosol spray into the cheek. It may be supplied as CBD oil containing only CBD as the active ingredient (excluding THC or terpenes), CBD-dominant hemp extract oil, capsules, dried cannabis, or prescription liquid solution. CBD does not have the same psychoactivity as THC, and can modulate the psychoactive effects of THC on the body if both are present. Conversion of CBD to THC can occur when CBD is heated to temperatures between 250–300 °C, potentially leading to its partial transformation into THC. In the United States, the cannabidiol drug Epidiolex was approved by the Food and Drug Administration (FDA) in 2018 for the treatment of two seizure disorders. While the 2018 United States Farm Bill removed hemp and hemp extracts (including CBD) from the Controlled Substances Act, the marketing and sale of CBD formulations for medical use or as an ingredient in dietary supplements or manufactured foods remains illegal under FDA regulation, as of 2024.
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Formula C8H8O4
Net Charge 0
Average Mass 168.14672
Monoisotopic Mass 168.04226
InChI InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)
InChIKey CFFZDZCDUFSOFZ-UHFFFAOYSA-N
SMILES OC(=O)Cc1ccc(O)c(O)c1
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
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ChEBI Ontology
Outgoing (3,4-dihydroxyphenyl)acetic acid (CHEBI:41941) has functional parent phenylacetic acid (CHEBI:30745)
(3,4-dihydroxyphenyl)acetic acid (CHEBI:41941) has role human metabolite (CHEBI:77746)
(3,4-dihydroxyphenyl)acetic acid (CHEBI:41941) is a catechols (CHEBI:33566)
(3,4-dihydroxyphenyl)acetic acid (CHEBI:41941) is a dihydroxyphenylacetic acid (CHEBI:61409)
(3,4-dihydroxyphenyl)acetic acid (CHEBI:41941) is conjugate acid of (3,4-dihydroxyphenyl)acetate (CHEBI:17612)
Incoming homovanillic acid (CHEBI:545959) has functional parent (3,4-dihydroxyphenyl)acetic acid (CHEBI:41941)
isohomovanillic acid (CHEBI:70818) has functional parent (3,4-dihydroxyphenyl)acetic acid (CHEBI:41941)
(3,4-dihydroxyphenyl)acetate (CHEBI:17612) is conjugate base of (3,4-dihydroxyphenyl)acetic acid (CHEBI:41941)
IUPAC Name
(3,4-dihydroxyphenyl)acetic acid
Synonyms Sources
2-(3,4-DIHYDROXYPHENYL)ACETIC ACID PDBeChem
3,4-Dihydroxyphenyl acetic acid KEGG COMPOUND
3,4-Dihydroxyphenylacetic acid KEGG COMPOUND
dopacetic acid NIST Chemistry WebBook
homoprotocatechuic acid NIST Chemistry WebBook
Manual Xrefs Databases
C01161 KEGG COMPOUND
DB01702 DrugBank
DHY PDBeChem
DOPAC Wikipedia
HMDB0001336 HMDB
View more database links
Registry Numbers Types Sources
102-32-9 CAS Registry Number NIST Chemistry WebBook
102-32-9 CAS Registry Number ChemIDplus
2211017 Beilstein Registry Number Beilstein
2211017 Reaxys Registry Number Reaxys
874810 Gmelin Registry Number Gmelin
Citations Types Sources
11251641 PubMed citation Europe PMC
11681538 PubMed citation Europe PMC
11868042 PubMed citation Europe PMC
15212971 PubMed citation Europe PMC
15862791 PubMed citation Europe PMC
18706927 PubMed citation Europe PMC
19191673 PubMed citation Europe PMC
22770225 PubMed citation Europe PMC
4420192 PubMed citation Europe PMC
Last Modified
09 December 2024