| Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Specifically it is used to treat cases that are Philadelphia chromosome-positive (Ph+). It is taken by mouth.
Common adverse effects include low white blood cells, low blood platelets, anemia, swelling, rash, and diarrhea. Severe adverse effects may include bleeding, pulmonary edema, heart failure, and prolonged QT syndrome. Use during pregnancy may result in harm to the fetus. It is a tyrosine-kinase inhibitor and works by blocking a number of tyrosine kinases such as Bcr-Abl and the Src kinase family.
Dasatinib was approved for medical use in the United States and in the European Union in 2006. It is on the World Health Organization's List of Essential Medicines. |
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InChI=1S/C18H38NO5P/c1- 2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1 |
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Mus musculus
(NCBI:txid10090)
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See:
MetaboLights Study
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Mus musculus
(NCBI:txid10090)
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Source: BioModels - MODEL1507180067
See:
PubMed
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sphingosine-1-phosphate receptor agonist
An agonist that binds to and activates sphingosine 1-phosphate receptors.
signalling molecule
A molecular messenger in which the molecule is specifically involved in transmitting information between cells. Such molecules are released from the cell sending the signal, cross over the gap between cells by diffusion, and interact with specific receptors in another cell, triggering a response in that cell by activating a series of enzyme controlled reactions which lead to changes inside the cell.
T-cell proliferation inhibitor
An inhibitor that interferes with the process of T-cell proliferation.
mouse metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
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vasodilator agent
A drug used to cause dilation of the blood vessels.
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View more via ChEBI Ontology
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(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
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(2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid
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HMDB
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(2S,3R,4E)-2-amino-4-octadecene-1,3-diol 1-(dihydrogen phosphate)
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ChemIDplus
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C18-Sphingosine 1-phosphate
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HMDB
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D-erythro-sphingosine 1-phosphate
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HMDB
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S1P
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ChEBI
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Sphing-4-enine 1-phosphate
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KEGG COMPOUND
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Sphingosine 1-phosphate
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KEGG COMPOUND
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Sphingosine 1-phosphic acid
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HMDB
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sphingosine-1-phosphate
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ChemIDplus
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26993-30-6
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CAS Registry Number
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ChemIDplus
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5877213
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Reaxys Registry Number
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Reaxys
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11278407
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11324700
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11418470
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