EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor |
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CHEBI:35664 |
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Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme. |
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This entity has been manually annotated by the ChEBI Team.
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Outgoing
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EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
(CHEBI:35664)
is a
EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor
(CHEBI:76835)
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Incoming
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3,3,5-trimethylcyclohexanol
(CHEBI:59065)
has role
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
(CHEBI:35664)
3-hydroxy-3-methylglutaric acid
(CHEBI:16831)
has role
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
(CHEBI:35664)
compactin diol lactone
(CHEBI:34652)
has role
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
(CHEBI:35664)
mevinic acid
(CHEBI:39508)
has role
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
(CHEBI:35664)
mevinolinic acid
(CHEBI:82985)
has role
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
(CHEBI:35664)
ML-236C
(CHEBI:34828)
has role
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
(CHEBI:35664)
monacolin J
(CHEBI:79034)
has role
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
(CHEBI:35664)
monacolin L
(CHEBI:50130)
has role
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
(CHEBI:35664)
simvastatin
(CHEBI:9150)
has role
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
(CHEBI:35664)
statin
(CHEBI:87631)
has role
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
(CHEBI:35664)
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HMG-CoA reductase inhibitor
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ChEBI
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HMG-CoA reductase inhibitors
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ChEBI
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hydroxymethylglutaryl-CoA reductase inhibitor
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ChEBI
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hydroxymethylglutaryl-CoA reductase inhibitors
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ChEBI
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1464741
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PubMed citation
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Europe PMC
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15531285
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PubMed citation
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Europe PMC
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20467214
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PubMed citation
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Europe PMC
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