CHEBI:35457 - EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor

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ChEBI Name EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor ChEBI ID CHEBI:35457 Definition An EC 3.4.15.* (peptidyl-dipeptidase) inhibitor that interferes with the action of peptidyl-dipeptidase A (EC 3.4.15.1). Stars This entity has been manually annotated by the ChEBI Team. Wikipedia License Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a class of medication used primarily for the treatment of high blood pressure and heart failure. This class of medicine works by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart. ACE inhibitors inhibit the activity of angiotensin-converting enzyme, an important component of the renin–angiotensin system which converts angiotensin I to angiotensin II, and hydrolyses bradykinin. Therefore, ACE inhibitors decrease the formation of angiotensin II, a vasoconstrictor, and increase the level of bradykinin, a peptide vasodilator. This combination is synergistic in lowering blood pressure. As a result of inhibiting the ACE enzyme in the bradykinin system, the ACE inhibitor drugs allow for increased levels of bradykinin which would normally be degraded. Bradykinin produces prostaglandin. This mechanism can explain the two most common side effects seen with ACE Inhibitors: angioedema and cough. Frequently prescribed ACE inhibitors include benazepril, zofenopril, perindopril, trandolapril, captopril, enalapril, lisinopril, and ramipril. Read full article at Wikipedia ChEBI Ontology Outgoing EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) is a antihypertensive agent (CHEBI:35674) EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) is a EC 3.4.15.* (peptidyl-dipeptidase) inhibitor (CHEBI:76782) Incoming (S,S,S)-nicotianamine (CHEBI:17721) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) N1,N8-bis-(dihydrocaffeoyl)spermidine (CHEBI:142881) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) Alacepril (CHEBI:31182) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) benazepril (CHEBI:3011) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) benazepril hydrochloride (CHEBI:3012) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) benazeprilat (CHEBI:88200) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) captopril (CHEBI:3380) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) cilazapril (CHEBI:3698) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) cilazapril monohydrate (CHEBI:145568) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) corilagin (CHEBI:3884) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) enalapril (CHEBI:4784) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) enalapril maleate (CHEBI:4785) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) enalaprilat (anhydrous) (CHEBI:4786) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) enalaprilat dihydrate (CHEBI:59877) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) fosinopril (CHEBI:5163) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) fosinopril sodium (CHEBI:5164) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) fosinoprilat (CHEBI:116962) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) imidapril (CHEBI:135654) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) imidaprilat (CHEBI:141520) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) lisinopril (CHEBI:43755) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) MK 351A (CHEBI:177385) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) perindopril (CHEBI:8024) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) perindopril arginine (CHEBI:77655) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) perindopril erbumine (CHEBI:8025) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) perindoprilat (CHEBI:132041) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) quercetin 3-O-α-(6'''-caffeoylglucosyl-β-1,2-rhamnoside) (CHEBI:66284) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) quinapril (CHEBI:8713) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) quinapril hydrochloride (CHEBI:8714) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) quinaprilat (CHEBI:140296) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) ramipril (CHEBI:8774) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) ramiprilat (CHEBI:77363) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) spirapril (CHEBI:135756) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) spiraprilat (CHEBI:141522) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) telmisartan (CHEBI:9434) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) trandolapril (CHEBI:9649) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) trandolaprilat (CHEBI:141521) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) zofenopril (CHEBI:78539) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) zofenopril calcium (CHEBI:82600) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) zofenoprilat (CHEBI:82602) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) zofenoprilat arginine (CHEBI:82603) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) Synonyms Sources ACE inhibitor ChEBI ACE inhibitors ChEBI angiotensin I-converting enzyme inhibitor ChEBI angiotensin I-converting enzyme inhibitors ChEBI angiotensin-converting enzyme inhibitor ChEBI angiotensin-converting enzyme inhibitors ChEBI carboxycathepsin inhibitor ChEBI carboxycathepsin inhibitors ChEBI DCP inhibitor ChEBI DCP inhibitors ChEBI dipeptidase inhibitor ChEBI dipeptidase inhibitors ChEBI dipeptide hydrolase inhibitor Note: (2013-12-23) Name is ambiguous. ChEBI dipeptide hydrolase inhibitors Note: (2013-12-23) Name is ambiguous. ChEBI dipeptidyl carboxypeptidase I inhibitor ChEBI dipeptidyl carboxypeptidase I inhibitors ChEBI dipeptidyl carboxypeptidase inhibitor ChEBI dipeptidyl carboxypeptidase inhibitors ChEBI EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitors ChEBI EC 3.4.15.1 inhibitor ChEBI EC 3.4.15.1 inhibitors ChEBI endothelial cell peptidyl dipeptidase inhibitor ChEBI endothelial cell peptidyl dipeptidase inhibitors ChEBI kininase II inhibitor ChEBI kininase II inhibitors ChEBI PDH inhibitor ChEBI PDH inhibitors ChEBI peptidase P inhibitor ChEBI peptidase P inhibitors ChEBI peptidyl dipeptidase A inhibitor ChEBI peptidyl dipeptidase A inhibitors ChEBI peptidyl dipeptidase I inhibitor ChEBI peptidyl dipeptidase I inhibitors ChEBI peptidyl dipeptidase-4 inhibitor ChEBI peptidyl dipeptidase-4 inhibitors ChEBI peptidyl dipeptide hydrolase inhibitor ChEBI peptidyl dipeptide hydrolase inhibitors ChEBI peptidyl-dipeptidase A (EC 3.4.15.1) inhibitor ChEBI peptidyl-dipeptidase A (EC 3.4.15.1) inhibitors ChEBI peptidyl-dipeptidase A inhibitor ChEBI peptidyl-dipeptidase A inhibitors ChEBI peptidyl-dipeptide hydrolase inhibitor ChEBI peptidyl-dipeptide hydrolase inhibitors ChEBI peptidyldipeptide hydrolase inhibitor ChEBI peptidyldipeptide hydrolase inhibitors ChEBI Manual Xref Database ACE_inhibitor Wikipedia View more database links Last Modified 04 November 2021