CHEBI:33283 - thiamine(1+) chloride

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ChEBI Name thiamine(1+) chloride
ChEBI ID CHEBI:33283
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information ZINC000095615753
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Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in stress responses. It is a releasing hormone that belongs to corticotropin-releasing factor family. In humans, it is encoded by the CRH gene. Its main function is the stimulation of the pituitary synthesis of adrenocorticotropic hormone (ACTH), as part of the hypothalamic–pituitary–adrenal axis (HPA axis). Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 196-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Increased CRH production has been observed to be associated with Alzheimer's disease and major depression, and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia. In addition to being produced in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta, CRH is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, CRH may act as a trigger for parturition. A recombinant version for diagnostics is called corticorelin (INN).
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Formula C12H17ClN4OS
Net Charge 0
Average Mass 300.80844
Monoisotopic Mass 300.08116
InChI InChI=1S/C12H17N4OS.ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);1H/q+1;/p-1
InChIKey MYVIATVLJGTBFV-UHFFFAOYSA-M
SMILES [Cl-].Cc1ncc(C[n+]2csc(CCO)c2C)c(N)n1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): water-soluble vitamin (role)
Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine.
(via B vitamin )
Application(s): nutraceutical
A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance.
(via B vitamin )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing thiamine(1+) chloride (CHEBI:33283) has part thiamine(1+) (CHEBI:18385)
thiamine(1+) chloride (CHEBI:33283) is a organic chloride salt (CHEBI:36094)
thiamine(1+) chloride (CHEBI:33283) is a vitamin B1 (CHEBI:26948)
IUPAC Name
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride
INNs Sources
thiamine WHO MedNet
thiamine WHO MedNet
thiaminum WHO MedNet
tiamina WHO MedNet
Synonyms Sources
3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium chloride ChemIDplus
Thiamin ChemIDplus
thiamine chloride DrugBank
thiamine monochloride ChemIDplus
vitamin B1 ChemIDplus
Manual Xrefs Databases
5819 ChemSpider
D08580 KEGG DRUG
DBSALT002650 DrugBank
Thiamine Wikipedia
View more database links
Registry Numbers Types Sources
318226 Gmelin Registry Number Gmelin
3581326 Beilstein Registry Number Beilstein
59-43-8 CAS Registry Number ChemIDplus
Citations Types Sources
23914634 PubMed citation Europe PMC
25552500 PubMed citation Europe PMC
Last Modified
15 July 2021