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| An acetate is a salt formed by the combination of acetic acid with a base (e.g. alkaline, earthy, metallic, nonmetallic or radical base). "Acetate" also describes the conjugate base or ion (specifically, the negatively charged ion called an anion) typically found in aqueous solution and written with the chemical formula C2H3O−2. The neutral molecules formed by the combination of the acetate ion and a positive ion (called a cation) are also commonly called "acetates" (hence, acetate of lead, acetate of aluminium, etc.). The simplest of these is hydrogen acetate (called acetic acid) with corresponding salts, esters, and the polyatomic anion CH3CO−2, or CH3COO−.
Most of the approximately 5 million tonnes of acetic acid produced annually in industry are used in the production of acetates, which usually take the form of polymers. In nature, acetate is the most common building block for biosynthesis. |
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Read full article at Wikipedia
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| InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 |
| QTBSBXVTEAMEQO-UHFFFAOYSA-M |
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Saccharomyces cerevisiae
(NCBI:txid4932)
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Source: yeast.sf.net
See:
PubMed
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Homo sapiens
(NCBI:txid9606)
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See:
DOI
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Saccharomyces cerevisiae metabolite
Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae ).
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
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View more via ChEBI Ontology
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acetate
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UniProt
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ACETATE ION
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PDBeChem
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acetic acid, ion(1−)
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ChemIDplus
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Azetat
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ChEBI
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CH3‒COO−
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IUPAC
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Ethanoat
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ChEBI
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ethanoate
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ChEBI
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MeCO2 anion
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NIST Chemistry WebBook
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ACET
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MetaCyc
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Acetate
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Wikipedia
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ACT
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PDBeChem
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C00033
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KEGG COMPOUND
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c0050
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UM-BBD
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DB03166
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DrugBank
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| View more database links |
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1379
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Gmelin Registry Number
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Gmelin
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1901470
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Reaxys Registry Number
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Reaxys
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71-50-1
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CAS Registry Number
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NIST Chemistry WebBook
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71-50-1
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CAS Registry Number
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ChemIDplus
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Kim YM, Lee SE, Park BS, Son MK, Jung YM, Yang SO, Choi HK, Hur SH, Yum JH (2012)
Proteomic analysis on acetate metabolism in Citrobacter sp. BL-4.
International journal of biological sciences 8, 66-78 [PubMed:22211106]
[show Abstract]
Mass production of glucosamine (GlcN) using microbial cells is a worthy approach to increase added values and keep safety problems in GlcN production process. Prior to set up a microbial cellular platform, this study was to assess acetate metabolism in Citrobacter sp. BL-4 (BL-4) which has produced a polyglucosamine PGB-2. The LC-MS analysis was conducted after protein separation on the 1D-PAGE to accomplish the purpose of this study. 280 proteins were totally identified and 188 proteins were separated as acetate-related proteins in BL-4. Acetate was converted to acetyl-CoA by acetyl-CoA synthetase up-regulated in the acetate medium. The glyoxylate bypass in the acetate medium was up-regulated with over-expression of isocitrate lyases and 2D-PAGE confirmed this differential expression. Using (1)H-NMR analysis, the product of isocitrate lyases, succinate, increased about 15 times in the acetate medium. During acetate metabolism proteins involved in the lipid metabolism and hexosamine biosynthesis were over-expressed in the acetate medium, while proteins involved in TCA cycle, pentose phosphate cycle and purine metabolism were down-regulated. Taken together, the results from the proteomic analysis can be applied to improve GlcN production and to develop metabolic engineering in BL-4. | Hosseini M, Ganjali MR, Veismohammadi B, Faridbod F, Abkenar SD, Salavati-Niasari M (2012)
Selective recognition of acetate ion based on fluorescence enhancement chemosensor.
Luminescence : the journal of biological and chemical luminescence 27, 341-345 [PubMed:22371380]
[show Abstract]
Fluorescence study of the complexation between uranyl salophen (L) and some common anions in acetonitrile-water (90:10, v/v) solution showed a tendency of L toward acetate ion (AcO-). The fluorescence enhancement of L is attributed to a 1:1 complex formation between L and acetate ion which was utilized as the basis for the selective detection of AcO-. The association constant of the 1:1 complex formation of L-AcO- was calculated as 6.60 × 10(6) . The linear response range of the fluorescent chemosensor covers a AcO- concentration range of 1.6 × 10(-7) to 2.5 × 10(-5) mol/L, with a detection limit of 2.5 × 10(-8) mol/L. L showed a selective and sensitive fluorescence enhancement response toward acetate ion over I3- , NO3-, CN-, CO3 (2-), Br-, Cl-, F-, H2 PO4- and SO4 (2-) , which was attributed to the higher stability of inorganic complex between acetate and L. | Salek RM, Maguire ML, Bentley E, Rubtsov DV, Hough T, Cheeseman M, Nunez D, Sweatman BC, Haselden JN, Cox RD, Connor SC, Griffin JL (2007)
A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human.
Physiological genomics 29, 99-108 [PubMed:17190852]
[show Abstract]
Type 2 diabetes mellitus is the result of a combination of impaired insulin secretion with reduced insulin sensitivity of target tissues. There are an estimated 150 million affected individuals worldwide, of whom a large proportion remains undiagnosed because of a lack of specific symptoms early in this disorder and inadequate diagnostics. In this study, NMR-based metabolomic analysis in conjunction with multivariate statistics was applied to examine the urinary metabolic changes in two rodent models of type 2 diabetes mellitus as well as unmedicated human sufferers. The db/db mouse and obese Zucker (fa/fa) rat have autosomal recessive defects in the leptin receptor gene, causing type 2 diabetes. 1H-NMR spectra of urine were used in conjunction with uni- and multivariate statistics to identify disease-related metabolic changes in these two animal models and human sufferers. This study demonstrates metabolic similarities between the three species examined, including metabolic responses associated with general systemic stress, changes in the TCA cycle, and perturbations in nucleotide metabolism and in methylamine metabolism. All three species demonstrated profound changes in nucleotide metabolism, including that of N-methylnicotinamide and N-methyl-2-pyridone-5-carboxamide, which may provide unique biomarkers for following type 2 diabetes mellitus progression. |
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