vitamin K |
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CHEBI:28384 |
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Any member of a group of fat-soluble 2-methyl-1,4-napthoquinones that exhibit biological activity against vitamin K deficiency. Vitamin K is required for the synthesis of prothrombin and certain other blood coagulation factors. |
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This entity has been manually annotated by the ChEBI Team.
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CHEBI:10009, CHEBI:27301, CHEBI:27307
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Mus musculus
(NCBI:txid10090)
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Source: BioModels - MODEL1507180067
See:
PubMed
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mouse metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
fat-soluble vitamin (role)
Any vitamin that dissolves in fats and are stored in body tissues. Unlike the water-soluble vitamins, they are stored in the body for long periods of time and generally pose a greater risk for toxicity when consumed in excess.
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View more via ChEBI Ontology
Outgoing
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vitamin K
(CHEBI:28384)
has role
fat-soluble vitamin (role)
(CHEBI:24020)
vitamin K
(CHEBI:28384)
has role
mouse metabolite
(CHEBI:75771)
vitamin K
(CHEBI:28384)
is a
1,4-naphthoquinones
(CHEBI:132142)
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Incoming
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16-oxonapyradiomycin A2
(CHEBI:215272)
is a
vitamin K
(CHEBI:28384)
delta7′′,8′′-6′′-hydroxynaphthomevalin
(CHEBI:223254)
is a
vitamin K
(CHEBI:28384)
demethylmenaquinone-12
(CHEBI:183114)
is a
vitamin K
(CHEBI:28384)
Dimethylmenaquinone DMMK-8
(CHEBI:203203)
is a
vitamin K
(CHEBI:28384)
Dimethylmenaquinone DMMK-8(VIII-H2)
(CHEBI:213116)
is a
vitamin K
(CHEBI:28384)
Hexahydromenaquinone MK-9(II,III,IX-H6)
(CHEBI:199901)
is a
vitamin K
(CHEBI:28384)
Hexahydromenaquinone MK-9(II,III,VIII-H6
(CHEBI:223473)
is a
vitamin K
(CHEBI:28384)
II,III-Tetrahydro-omega-(2,6,6-trimethylcyclohex-2-enylmethyl)menaquinone-6
(CHEBI:211818)
is a
vitamin K
(CHEBI:28384)
menadione
(CHEBI:28869)
is a
vitamin K
(CHEBI:28384)
menaquinone
(CHEBI:16374)
is a
vitamin K
(CHEBI:28384)
Menaquinone MK-8(VIII-H2)
(CHEBI:213307)
is a
vitamin K
(CHEBI:28384)
Menaquinone-10 (II-, III-H4)
(CHEBI:212483)
is a
vitamin K
(CHEBI:28384)
Merochlorin D
(CHEBI:205165)
is a
vitamin K
(CHEBI:28384)
Merochlorin E
(CHEBI:209932)
is a
vitamin K
(CHEBI:28384)
Merochlorin F
(CHEBI:209936)
is a
vitamin K
(CHEBI:28384)
Methylmenaquinone MMK-8
(CHEBI:213392)
is a
vitamin K
(CHEBI:28384)
Methylmenaquinone MMK-8(VIII-H2)
(CHEBI:197829)
is a
vitamin K
(CHEBI:28384)
MK-8
(CHEBI:205208)
is a
vitamin K
(CHEBI:28384)
Napyradiomycin A3
(CHEBI:209527)
is a
vitamin K
(CHEBI:28384)
Octahydromenaquinone MK-9(II,III,VIII,IX)
(CHEBI:203045)
is a
vitamin K
(CHEBI:28384)
phylloquinone
(CHEBI:18067)
is a
vitamin K
(CHEBI:28384)
SF2415B1
(CHEBI:212648)
is a
vitamin K
(CHEBI:28384)
Tetrahydrom
(CHEBI:221751)
is a
vitamin K
(CHEBI:28384)
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Vitamin K
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KEGG COMPOUND
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vitamin K vitamer
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ChEBI
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vitamin K vitamers
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ChEBI
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vitamine K
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ChEBI
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vitamins K
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ChEBI
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12001-79-5
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CAS Registry Number
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KEGG COMPOUND
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12001-79-5
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CAS Registry Number
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ChemIDplus
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D'Souza K, Kim YJ, Balla T, Epand RM (2014) Distinct properties of the two isoforms of CDP-diacylglycerol synthase. Biochemistry 53, 7358-7367 [PubMed:25375833] [show Abstract] CDP-diacylglycerol synthases (CDS) are critical enzymes that catalyze the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA). Here we show in vitro that the two isoforms of human CDS, CDS1 and CDS2, show different acyl chain specificities for its lipid substrate. CDS2 is selective for the acyl chains at the sn-1 and sn-2 positions, the most preferred species being 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid. CDS1, conversely, shows no particular substrate specificity, displaying similar activities for almost all substrates tested. Additionally, we show that inhibition of CDS2 by phosphatidylinositol is also acyl chain-dependent, with the strongest inhibition seen with the 1-stearoyl-2-arachidonoyl species. CDS1 shows no acyl chain-dependent inhibition. Both CDS1 and CDS2 are inhibited by their anionic phospholipid end products, with phosphatidylinositol-(4,5)-bisphosphate showing the strongest inhibition. Our results indicate that CDS1 and CDS2 could create different CDP-DAG pools that may serve to enrich different phospholipid species with specific acyl chains. |
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