CHEBI:22660 - aspartic acid

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ChEBI Name aspartic acid ChEBI ID CHEBI:22660 Definition An α-amino acid that consists of succinic acid bearing a single α-amino substituent Stars This entity has been manually annotated by the ChEBI Team. Supplier Information ChemicalBook:CB6705020, eMolecules:518145, eMolecules:883971, ZINC000006661227 Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Wikipedia License l-DOPA, also known as l-3,4-dihydroxyphenylalanine and used medically as levodopa, is made and used as part of the normal biology of some plants and animals, including humans. Humans, as well as a portion of the other animals that utilize l-DOPA, make it via biosynthesis from the amino acid l-tyrosine. l-DOPA is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), which are collectively known as catecholamines. Furthermore, l-DOPA itself mediates neurotrophic factor release by the brain and CNS. In some plant families (of the order Caryophyllales), l-DOPA is the central precursor of a biosynthetic pathway that produces a class of pigments called betalains. l-DOPA can be manufactured and in its pure form is sold as a drug with the INNTooltip International Nonproprietary Name levodopa. Trade names include Sinemet, Pharmacopa, Atamet, and Stalevo. As a drug, it is used in the treatment of Parkinson's disease and dopamine-responsive dystonia, as well as restless leg syndrome. l-DOPA has a counterpart with opposite chirality, d-DOPA. As is true for many molecules, the human body produces only one of these isomers (the l-DOPA form). The enantiomeric purity of l-DOPA may be analyzed by determination of the optical rotation or by chiral thin-layer chromatography. Read full article at Wikipedia Formula C4H7NO4 Net Charge 0 Average Mass 133.10272 Monoisotopic Mass 133.03751 InChI InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9) InChIKey CKLJMWTZIZZHCS-UHFFFAOYSA-N SMILES NC(CC(O)=O)C(O)=O Metabolite of Species Details Daphnia magna (NCBI:txid35525) See: Mixtures of similarly acting compounds in Daphnia magna: From gene to metabolite and beyondTine Vandenbrouck, Oliver A.H. Jones, Nathalie Dom, Julian L. Griffin, Wim De CoenEnvironment International 36 (2010) 254-268 Roles Classification Chemical Role(s): Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Bronsted base). (via oxoacid ) Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound ) Biological Role(s): fundamental metabolite Any metabolite produced by all living cells. View more via ChEBI Ontology ChEBI Ontology Outgoing aspartic acid (CHEBI:22660) has part carboxymethyl group (CHEBI:41402) aspartic acid (CHEBI:22660) has role fundamental metabolite (CHEBI:78675) aspartic acid (CHEBI:22660) is a α-amino acid (CHEBI:33704) aspartic acid (CHEBI:22660) is a C4-dicarboxylic acid (CHEBI:66873) aspartic acid (CHEBI:22660) is a polar amino acid (CHEBI:26167) aspartic acid (CHEBI:22660) is conjugate acid of aspartate (CHEBI:132943) aspartic acid (CHEBI:22660) is conjugate acid of aspartate(1−) (CHEBI:35391) Incoming α-Asp-Leu (CHEBI:68596) has functional parent aspartic acid (CHEBI:22660) β-Asp-Ile (CHEBI:68601) has functional parent aspartic acid (CHEBI:22660) β-Asp-Leu (CHEBI:68600) has functional parent aspartic acid (CHEBI:22660) D-aspartic acid (CHEBI:17364) is a aspartic acid (CHEBI:22660) L-aspartic acid (CHEBI:17053) is a aspartic acid (CHEBI:22660) aspartic acid-1,4-13C2 (CHEBI:176633) is a aspartic acid (CHEBI:22660) aspartate (CHEBI:132943) is conjugate base of aspartic acid (CHEBI:22660) aspartate(1−) (CHEBI:35391) is conjugate base of aspartic acid (CHEBI:22660) α-aspartyl group (CHEBI:22445) is substituent group from aspartic acid (CHEBI:22660) β-aspartyl group (CHEBI:22832) is substituent group from aspartic acid (CHEBI:22660) aspartic acid residue (CHEBI:32470) is substituent group from aspartic acid (CHEBI:22660) asparto group (CHEBI:22662) is substituent group from aspartic acid (CHEBI:22660) aspartoyl group (CHEBI:22663) is substituent group from aspartic acid (CHEBI:22660) IUPAC Name aspartic acid Synonyms Sources (+-)-Aspartic acid ChemIDplus (R,S)-Aspartic acid ChemIDplus 2-aminobutanedioic acid IUPAC Asp ChEBI Aspartic acid KEGG COMPOUND D ChEBI DL-Aminosuccinic acid ChemIDplus DL-Asparagic acid ChemIDplus Manual Xrefs Databases Aspartic_acid Wikipedia C16433 KEGG COMPOUND View more database links Registry Numbers Types Sources 185140 Gmelin Registry Number Gmelin 617-45-8 CAS Registry Number NIST Chemistry WebBook 617-45-8 CAS Registry Number ChemIDplus 774618 Reaxys Registry Number Reaxys Citation Type Source 22264337 PubMed citation Europe PMC Last Modified 28 June 2021