CHEBI:176419 - FIN56

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ChEBI Name FIN56
ChEBI ID CHEBI:176419
Definition A fluorene that is N-9H-fluoren-9-ylidenehydroxylamine substituted by N-cyclohexylsulfonyl groups at positions 2 and 7. It induces ferroptosis via degradation of GPX4 and also binds and activates squalene synthase.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information No supplier information found for this compound.
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Formula C25H31N3O5S2
Net Charge 0
Average Mass 517.660
Monoisotopic Mass 517.17051
InChI InChI=1S/C25H31N3O5S2/c29-26-25-23-15-19(34(30,31)27-17-7-3-1-4-8-17)11-13-21(23)22-14-12-20(16-24(22)25)35(32,33)28-18-9-5-2-6-10-18/h11-18,27-29H,1-10H2
InChIKey JLCFMMIWBSZOIS-UHFFFAOYSA-N
SMILES ON=C1C2=C(C=CC(=C2)S(=O)(=O)NC2CCCCC2)C2=C1C=C(C=C2)S(=O)(=O)NC1CCCCC1
Roles Classification
Biological Role(s): ferroptosis inducer
Any substance that induces or promotes ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
EC 1.11.1.9 (glutathione peroxidase) inhibitor
An inhibitor of peroxidases (EC 1.11.1.*) that inhibits the action of glutathione peroxidase (EC 1.11.1.9).
xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
(via fluorenes )
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ChEBI Ontology
Outgoing FIN56 (CHEBI:176419) has functional parent 9-hydroxyiminofluorene-2,7-disulfonamide (CHEBI:114722)
FIN56 (CHEBI:176419) has role EC 1.11.1.9 (glutathione peroxidase) inhibitor (CHEBI:176342)
FIN56 (CHEBI:176419) has role ferroptosis inducer (CHEBI:173085)
FIN56 (CHEBI:176419) is a fluorenes (CHEBI:24059)
FIN56 (CHEBI:176419) is a ketoxime (CHEBI:24983)
FIN56 (CHEBI:176419) is a sulfonamide (CHEBI:35358)
IUPAC Name
N,N'-dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
Synonyms Sources
FIN 56 ChEBI
FIN-56 ChEBI
N2,N7-dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide IUPAC
Registry Number Type Source
1083162-61-1 CAS Registry Number ChEBI
Citations Types Sources
27159577 PubMed citation Europe PMC
27315536 PubMed citation Europe PMC
29610484 PubMed citation Europe PMC
30057310 PubMed citation Europe PMC
30686534 PubMed citation Europe PMC
30863316 PubMed citation Europe PMC
31441366 PubMed citation Europe PMC
33414455 PubMed citation Europe PMC
Last Modified
07 June 2021